胃粘膜良恶性病变中bcl-2、bax、c-myc基因蛋白表达及意义  

THE EXPRESSION AND SIGNIFICANCE OF DCL-2, BOX AND C - MYC IN GASTRIC MUCOSA DENIGN - MALIGNANT LESSIONS

作　　者：戴洁[1] 祁晓莉[1] 于淑霞[1] 王淑强[1] 许永利[1] 

机构地区：[1]张家口医学院,075000

出　　处：《神经药理学报》1999年第4期32-,34,共2页Acta Neuropharmacologica

摘　　要：为探讨凋亡相关基因bcl-2、bax、c-myc在胃癌发生发展中的作用,我们采用SP免疫组织化学方法对125例胃粘膜良恶性病变标本进行bcl 2、bax、c-myc基因蛋白的检测。结果表明,bcl-2和bax在胃癌、胃炎伴肠化生和异型增生组的阳性表达率显著高于单纯胃炎组,且bcl-2的表达与胃癌分化程度有关。此实验提示bcl-2、bax和c-myc基因可能参与胃癌的发生和发展。To investigate the role of bcl-2,bax and c-myc in oncogenesis and progression of gastric cancer (GC),The expression of bcl-2,bax and c-myc were detected in 125 gastric mucosa lesions tissue by immunohisto-chemistry.Result:The positive rate of bcl-2 and bax protein were significant higher in GC and gastritis with intestinal metaplasia and dysplasia than simple gastritis,and the expression of bcl-2 were related to the degree of differentiated GC.The result showed that bcl-2,bax and c-myc may play an role in the gncogenesis and progression of GC.

关 键 词：凋亡 胃炎 胃癌 表达 

分 类 号：R735.2[医药卫生—肿瘤]