薏苡仁注射液联合羟喜树碱治疗老年晚期非小细胞肺癌恶性胸腔积液的疗效及机制  

Effect and mechanism of Kanglaite combined with hydroxycamptothecin (HCPT) to treat patients of non-small cell lung cancer with malignant pleural effusion in elderly

作　　者：萧娟 王亚珍[2] 甄严杰[3] 吕品田[2] 

机构地区：[1]秦皇岛市海港区疾病预防控制中心检验科,河北秦皇岛066000 [2]河北省人民医院肿瘤科 [3]河北医科大学第二医院心内科

出　　处：《中国老年学杂志》2011年第21期4092-4094,共3页Chinese Journal of Gerontology

基　　金：河北省中医药管理局科研基金资助项目(2009048)

摘　　要：目的观察薏苡仁注射液(康莱特)联合羟喜树碱对老年(≥60岁)晚期非小细胞肺癌恶性胸腔积液的治疗效果,并对其机制进行分析。方法接受胸腔药物注射的确诊为晚期非小细胞肺癌恶性胸腔积液老年患者共68例,其中联合用药组38例、羟喜树碱组30例,观察治疗效果,并检测胸水生化指标(乳酸脱氢酶、总胆固醇、腺苷脱氨酶)、外周血免疫细胞亚群及胸腔脱落细胞凋亡相关因子(Survivin、Bcl-2、Bax)mRNA的变化情况。结果联合用药组近期有效率为86.84%(33/38),高于对照组的76.67%(23/30)(P<0.05);联合用药组在生化指标及免疫指标方面优于对照组(均P<0.05);治疗后联合用药组病人凋亡抑制因子Survivin、Bcl-2的mRNA表达下降,而促凋亡因子Bax的mRNA表达升高(均P<0.05);与对照组比较,联合用药组各因子的变化更为明显。结论康莱特联合羟喜树碱治疗老年晚期非小细胞肺癌恶性胸腔积液效果良好并可有效改善免疫功能,其机制可能与康莱特调控凋亡相关蛋白的表达有关。Objective To evaluate the effect and mechanism of coix seed injection（Kanglaite） combined with hydroxycamptothecin（HCPT） to treat the old patients of non-small cell lung cancer（NSCLC） with malignant pleural effusion.Methods 68 cases（≥60 years） were divided into 2 groups.The combination group was 38 cases,and HCPT group 30 cases.Effect of these groups was observed,and biochemical index（LDH,TC,ADA）,immune cell subsets in peripheral blood and apoptosis-related proteins（Survivin,Bcl-2,Bax） were also tested.Results Recent efficient（86.84%） of combination group was higher than that of HCPT group（76.67%）.Changes of biochemical index and immune function were better in combination group than those of HCPT group（all P0.05）.Expression of Survivin,Bcl-2 mRNA were decreased after treatment in both groups,while Bax mRNA increased in combination group（all P0.05）.Compared with HCPT group,mRNA of these factors changed more significantly in combination group.Conclusions Kanglaite combined with HCPT have an good effect on NSCLC with pleural effusion and can improve the immune function,which maybe have relation with Kanglaite′s regulating apoptosis related protein expression.

关 键 词：薏苡仁注射液(康莱特) 肺肿瘤 胸腔积液 药物疗法 老年人 

分 类 号：R734.2[医药卫生—肿瘤]