结肠癌术前化疗疗效的病理组织学对照研究  

Histological comparative sutdy of selectively preoperative intra arterial infusion chemotherapy in colorectal cancer

作　　者：许健[1] 陈君坤[1] 刘福坤[1] 吴波[1] 黄伟[1] 曹建民[1] 李成郎[1] 

机构地区：[1]南京军区南京总医院医学影像科

出　　处：《医学研究生学报》1998年第1期26-29,共4页Journal of Medical Postgraduates

摘　　要：目的：为探讨和评价结肠癌术前化疗的方法及作用，作者对本院同期手术治疗的１１４例结肠癌病例进行了研究。方法：根据术前化疗方法分为：（１）动脉灌注化疗组６２例；（２）静脉化疗组１９例；（３）５－氟脲嘧啶（５－Ｆｕ）保留灌肠组１２例；（４）对照组２１例。化疗后２～４周行肿瘤切除术，肿瘤标本作病理切片组织学疗效观察。结果：前三组化疗后切除的肿瘤其细胞变性、坏死数量及程度均明显高于对照组（Ｐ＜０．０１），其中动脉灌注化疗组高于静脉化疗组和５－Ｆｕ保留灌肠组（Ｐ＜０．０５）。４０例使用５－Ｆｕ动脉灌注化疗组中８例出现化学性肠炎，其中两例出现肠缺血坏死。结论：结肠癌术前化疗以动脉灌注化疗效果最好，应作为首选；５－Ｆｕ作为结肠癌术前动脉灌注化疗疗效不显著而不良反应明显。Objectives:111 patients with colorectal cancer receiving surgical resection were studied in order to investigate the method and therapeutic effect of preoperation. Methods:The patients were divided into 4 groups according to preoperative chemotherapy:(1)intra arterial infusion chemotherapy (IAIC) group ( n =62);(2)intravenous chemotherapy group ( n =16);(3)5 Fluorouracil retention enema group ( n =12);(4)cnotrol group ( n =21).The tumor of all cases were resected within 2￣4 weeks after chemotherapy and histological examination of the resected specimens for evaluating the therapeutic effect were performed. Results:The cell necrosis of tumor in the first three groups were more obvious than control group( P <0.01),and group (1) was more obvious than group (2) or group (3) ( P <0.05).There were 8 cases with chemoentercitis (2 of them with intestines ischemic necrosis) in the 40 cases using 5 Fu in IAIC. Conclusions:In the preopertive chmotherapies of the colorectal cancer,the most effective therapy was IAIC.5 Fu had no significant effect in the IAIC.

关 键 词：结肠癌 动脉灌注 化学治疗 组织学疗效观察 

分 类 号：R735.35[医药卫生—肿瘤]