Caveolin-1在肝细胞肝癌中的表达及意义  

Clinical significance of Caveolin-1 in hepatocellular carcinoma

作　　者：李琳[1] 廖永晖[1] 汤雨[2] 千年松[3] 张洪涛[1] 李俊杰[1] 李伟民[1] 陶开山[1] 

机构地区：[1]第四军医大学西京医院肝胆胰脾外科移植中心,陕西西安710032 [2]解放军302医院超声科,北京100039 [3]解放军总医院肝胆外科,北京100853

出　　处：《现代肿瘤医学》2011年第11期2262-2265,共4页Journal of Modern Oncology

基　　金：国家自然科学基金(编号:30772094)

摘　　要：目的:研究Caveolin-1(Cav-1)在肝细胞肝癌(HCC)中的表达及其与临床病理参数、预后之间的关系。方法:利用免疫组化方法检测160例HCC组织中Cav-1的表达情况,并分析其与临床病理参数和预后的关系。结果:160例肝癌标本中,65例(41%)标本为Cav-1阴性,95例(59%)标本为Cav-1阳性。肝癌组织Cav-1阳性细胞表现出典型的细胞膜表达。单因素分析结果显示Cav-1在HCC癌组织的表达与肿瘤的分化、门静脉侵犯、肝内转移和复发有关,差异均具有统计学意义(P<0.05);K-M生存曲线显示Cav-1阴性表达组生存率高于Cav-1阳性表达组,差异具有统计学意义(P<0.001)。多因素COX逐步回归分析结果显示Cav-1是总体生存率(P=0.047)的独立因素。结论:Cav-1在HCC中的过表达,对HCC的发生、发展、侵袭转移及预后可能起重要作用。Objective：To study the clinical significance of Caveolin-1（Cav-1）in hepatocellular carcinoma.Methods：One hundred and sixty cases of hepatocellular carcinoma were tested for expression of Cav-1 by SP immunohistochemistry.Results： Out of 160 HCC samples,65（41%）were negative for Caveolin-1,95（59%） were positive.The Cav-1-positive cells in HCC tissues showed unequivocal cytoplasmic staining pattern.The positive rate of Cav-1 expression was significantly correlated with histological differentiation,portal venous invasion,intrahepatic metastasis and recurrence（P0.05）.K-M survival curve showed the survival rate was significantly lower in the positive expression of the Cav-1 patients compared to the negative ones（P0.001）.The Multivariate COX proportional hazards model analysis also showed that the expression of Cav-1 was an independent predictor of overall survival（P=0.047）.Conclusion： Cav-1 may play an important role in the development and metastasis of hepatocellular cancer.

关 键 词：肝细胞癌 小凹蛋白 免疫组织化学 

分 类 号：R735.7[医药卫生—肿瘤]