CD133 and membrane microdomains:Old facets for future hypotheses  

作　　者：Christine A Fargeas Jana Karbanová József Jászai Denis Corbeil 

机构地区：[1]Tissue Engineering Laboratories (BIOTEC),Technische Universitt Dresden,D-01307 Dresden,Germany

出　　处：《World Journal of Gastroenterology》2011年第36期4149-4152,共4页世界胃肠病学杂志（英文版）

基　　金：Supported by Deutsche Forschungsgemeinschaft(TRR83 No.6;SFB655 B3;CO298/5-1)

摘　　要：Understanding all facets of membrane microdomains in normal and cancerous cells within the digestive tract is highly important,not only from a clinical point of view,but also in terms of our basic knowledge of cellular transformation.By studying the normal and cancer stem cell-associated molecule CD133 (prominin-1),novel aspects of the organization and dynamics of polarized epithelial cells have been revealed during the last decade.Its association with particular membrane microdomains is highly relevant in these contexts and might also offer new avenues in diagnosis and/or targeting of cancer stem cells.Understanding all facets of membrane microdomains in normal and cancerous cells within the digestive tract is highly important,not only from a clinical point of view,but also in terms of our basic knowledge of cellular transformation.By studying the normal and cancer stem cell-associated molecule CD133 （prominin-1）,novel aspects of the organization and dynamics of polarized epithelial cells have been revealed during the last decade.Its association with particular membrane microdomains is highly relevant in these contexts and might also offer new avenues in diagnosis and/or targeting of cancer stem cells.

关 键 词：AC133 Cancer CD133 Membrane microdomains Membrane vesicles Prominin-1 Stem cell 

分 类 号：R735.3[医药卫生—肿瘤]