An Experimental Comparative Study on the Characteristicsof Ventricular Fibrillation during Cardiac Arrest and Methoxamine Administration  

作　　者：潘铁成 周淑华 

出　　处：《Journal of Huazhong University of Science and Technology(Medical Sciences)》1997年第2期94-97,共4页华中科技大学学报（医学英德文版）

摘　　要：The effect of a pure α-adrenergic agent, methoxamine on ventricularfibrillation (VF) amplitude and the relation between hemodynamic parameters andsurvival in a rodent cardiopulmonary resuscitation (CPR) model were studied.Our results suggested that: 1) VF amplitude decreased during untreated VF, butit increased during pericardial chest compression ; 2) methoxamine significantly increased the mean aortic pressure (MAP) and coronary perfusion pressure (CPP)but not VF amplitude, and the survival also increased due to elevation of CPP;and 3) all surviving animals with successful defibrillhtion had a higher VF ampli-tude.The effect of a pure α-adrenergic agent, methoxamine on ventricularfibrillation (VF) amplitude and the relation between hemodynamic parameters andsurvival in a rodent cardiopulmonary resuscitation (CPR) model were studied.Our results suggested that: 1) VF amplitude decreased during untreated VF, butit increased during pericardial chest compression ; 2) methoxamine significantly increased the mean aortic pressure (MAP) and coronary perfusion pressure (CPP)but not VF amplitude, and the survival also increased due to elevation of CPP;and 3) all surviving animals with successful defibrillhtion had a higher VF ampli-tude.

关 键 词：ventricular fibrillation cardiopulmonary resuscitation METHOXAMINE 

分 类 号：R363[医药卫生—病理学]