内皮素水平在脑卒中病人中的意义  

The Significance of the Level of Endothelins in Patients with Stroke

作　　者：路月霞 刘有恩[2] 梅林[2] 冯立忠[2] 王建东[2] 张瞳光[2] 李蕴 

机构地区：[1]青岛市市北区医院,266012 [2]青岛市人民医院 [3]青岛市橡胶公司医院

出　　处：《青岛医药卫生》1997年第5期8-9,共2页Qingdao Medical Journal

摘　　要：报道用放免法测定102例脑卒中病人血浆内皮素(ET)在发病急性期及恢复期的水平变化。结果提示:ET水平在TIA与脑供血不足病人高于对照组。脑梗塞病人急性期及恢复期ET水平较对照组有显著差异(P<0.01),ET水平与梗塞范围正相关。SAH病人发病一周内ET值迅速升高,两周内达高峰,五周内即降至原有水平。作者认为:ET参与了卒中的发生及发展过程,是导致脑血管痉挛及脑缺血的主要因素。The plasma endothelins(ET) were detected by radioimmunoassay in 102 patients with stroke in acute and restoration stage. The results showed that the level of plasma ET in patients with transient is-chemic attack and cerebral ischmia increased significantly as compared with the controls. A marked elevations of plasma ET was observed in acute and restoration stage of patients with cerebral infaction (P < 0. 01 ). There was a positive correlation between the level of plasma endothelins and the cerebral infarct fields. The level of plasma ET increased at once in the first week. It was summit in 2 weeks. It returned to the normal level in 5 weeks. The authors suggested:This study showed that ET may contribute to the patho-genesis and development of stroke. It may be a main factor of causing vasospasm and cerebral ischemic injury.

关 键 词：内皮素 脑血管痉挛 脑缺血 蛛网膜下腔出血 

分 类 号：R743.3[医药卫生—神经病学与精神病学]