三叉神经痛的分子发病机制的研究进展  

Progress on molecular pathogenesis of trigeminal neuralgia

作　　者：吴饶平[1] 熊伟[2] 高云[1] 

机构地区：[1]南昌大学医学院生理学教研室,江西南昌330006 [2]南昌大学附属口腔医院,江西南昌330006

出　　处：《中国药理学通报》2011年第11期1487-1490,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No30860333);江西省卫生厅资助项目(No20101066)

摘　　要：三叉神经痛(trigeminal neuralgia,TN)是指三叉神经的一支或几支分布区的反复性、阵发性剧痛,对病人的生活质量影响较大的一种较难完全治愈的疾病,临床一般分为原发性和继发性TN。关于原发性TN的病因和发病机制目前尚不明确。现在,随着分子生物学研究的进展,已经发现多种神经类物质和TN有着密切的联系。该文从分子方面对TN的发病机制研究进展情况作一综述,旨在为TN的治疗提供理论依据。Trigeminal neuralgia（TN）is a recurrent and parox-ysmal pain in regions innervated by one or several branches of trigeminal nerve.It has a great impact on the quality of patients＇ life and is difficult to cure completely.Generally,TN is divided into primary and secondary TN in clinical practice.At present,the etiology and pathogenesis of TN remain unclear.With the progress of molecular biology,it has been found that a variety of nerve substances are closely linked with TN.In this paper,a review has been made on pathogenesis and research progress of trigeminal neuralgia from the point of molecular mechanism,hoping to find a theoretical basis for the treatment of trigeminal neuralgia.

关 键 词：三叉神经痛 发病机制 分子机制 降钙素基因相关肽 P物质 三磷酸腺苷 

分 类 号：R-05[医药卫生] R745.110.2