孟鲁司特对氯胺酮镇痛效应的影响  

Effect of montelukast on ketamine′s analgesic action

作　　者：武玉清[1] 史晓甜[2] 梁拓[2] 张永 周成华[2] 

机构地区：[1]徐州医学院麻醉药理学教研室,江苏徐州221002 [2]徐州医学院药理学教研室,江苏徐州221002 [3]徐州市第六人民医院,江苏徐州221004

出　　处：《中国药理学通报》2011年第11期1570-1574,共5页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No81070889;81171013);江苏省高校自然科学基金重大资助项目(No10KJA320052);江苏省高校大学生实践创新训练计划资助项目(No2010797);江苏省青蓝工程优秀青年骨干教师资助项目

摘　　要：目的观察白三烯受体拮抗剂孟鲁司特对静脉麻醉药氯胺酮镇痛效应的影响。方法取40只小鼠,♀♂各半,随机分为4组:生理盐水对照组(NS)、氯胺酮处理组(K)、孟鲁司特处理组(M)、孟鲁司特和氯胺酮联合用药组(M+K)。通过醋酸致小鼠扭体法观察小鼠给药后扭体潜伏期和次数的变化。另取40只小鼠,♀♂各半,随机分为上述4组,利用甩尾实验分别观察给药后小鼠对热水和冰水痛阈值的改变。第3批实验再取40只♀♂小鼠,随机分为上述4组,采用热板法检测给药后小鼠痛阈值的变化。结果孟鲁司特单独用药对小鼠扭体潜伏期和次数、热水和冰水甩尾痛阈值、以及热板痛阈值均无明显影响;氯胺酮能够延长醋酸致小鼠扭体的潜伏期,并且减少醋酸致小鼠扭体的次数,升高小鼠对热水、冰水甩尾和热板痛阈值;而孟鲁司特能够进一步增强氯胺酮的这些效应。结论孟鲁司特能够明显增强氯胺酮对小鼠的镇痛效应。Aim To observe the analgesic effects of ketamine combined with montelukast in mice.Methods 40 mice were randomly divided into 4 groups： normal saline group（NS）,ketamine group（K）,montelukast group（M） and montelukast combined with ketamine group（M＋K）.The method of stretching induced by acetic acid was adopted.In another experiment,40 mice were randomly divided into 4 groups as above.The pain threshold of mice to hot and ice water was observed through tail-flick experiment.In the third experiment,40 female mice were randomly divided into 4 groups as above.The hot-plate pain threshold（HPPT） was evaluated by hot-plate test.Results Ketamine prolonged stretching latent time and reduced the stretching times.In addition,ketamine increased tail-flick pain threshold to hot or ice water and elevated the hot-plate pain threshold（HPPT）.These analgesic effects of ketamine were markedly enhanced by montelukast.Conclusion Montelukast can enhance the analgesic effect of ketamine in mice.

关 键 词：氯胺酮 孟鲁司特 镇痛效应 小鼠 扭体反应 甩尾实验 热板实验 

分 类 号：R-332[医药卫生] R969.2