p53肿瘤抑制基因在食管鳞状细胞癌病人临床预后上的意义  

Eevaluation of p53 proteinas overexpression an independent prognostic factor in esophageal squamous cell carcinoma

作　　者：何丹[1] 曹世华[1] 廖琼[2] 何跃 Frank HW 

机构地区：[1]香港大学医学院解剖系 [2]四川省肿瘤医院

出　　处：《中华消化杂志》1996年第S1期29-31,共3页Chinese Journal of Digestion

摘　　要：采用DO-7蛋白单克隆抗体及微波加热处理方法,对174例食管鳞状细胞癌石蜡包埋的手术切除标本进行免疫组化染色,并将其结果与临床病理资料进行多元相关统计学分析.同时采用Cox模型生存危险比率分析方法,对111例有5年临床随访的病人进行生存统计学分析。研究结果显示,p53阳性表达与年龄、性别、肿瘤分化及临床分期没有显著关系,但p53阳性表达病人的临床预后差于不表达的病人(P<0.05),特别是临床Ⅱ期病人.结果提示,p53的表达可以作为食管鳞癌预后的一种判断指标。Mutation and overexpression of the tumor suppressor gene product, p53, is believed to play an important role in the development of human malignant tumors. Many studies shows that overxpression of the mutant p53 gene product is common in human malignant tumours including esophageal cancer. However, the prognostic significance of overexpression of p53 gene is not well defined. In this study, we have investigated the overexpression of p53 gene product in 174 esophageal squamous cell carcinoma collected from Sichuan Cancer Hospital, Chengdu, China. 48.9% of these esophageal squamous cell carcinomas were positive for p53 staining. Correlations of overexpression of p53 with clinicopathological features including histological type and grade, clinical staging, age and sex was analyzed in all specimens. The prognostic significance of p53 stained esophageal squamous cell carcinoma was analyzed in 111 of these patients follow-up for five-year. Significant statistical correlations were observed between p53 positive and poor prognosis analyzed by Cox proportional hazard regression analysis, (F=0.04). No statistically significant differences were observed between p53 overexpression and the clinicopathological factors including age, sex, differentiation and clinical staging of the cancer, but patients with Vositioly expressed p53 has a poorer prognosis than those with negative expression. The present study indicate that overexpression of p53 may be a useful independent prognostic factor in esophageal squamous cell carcinoma at its early stage.

关 键 词：食管鳞癌 P53 临床预后 

分 类 号：R735.1[医药卫生—肿瘤]