鼻咽癌原发灶热疗的初步研究  

Preliminarystudyofhyperthermiaforprimarynasopharyngealcancer(NPC)

作　　者：钟强荣[1] 李楚玉[1] 吴敬波[1] 曾智帆[1] 

机构地区：[1]广州中山医科大学肿瘤医院放疗科

出　　处：《中华放射肿瘤学杂志》1996年第3期32-35,共4页Chinese Journal of Radiation Oncology

摘　　要：目的：提高鼻咽癌放疗效果及减轻副作用，寻找理想的鼻咽癌局部热疗的方法，并积累临床数据和经验。材料与方法：用两种微波腔内辐射器（２４５０ＭＨｚ和９１５ＭＨｚ），对肌肉体模和病人的鼻咽腔内加温，并用８ＭＨｚ射频对鼻咽两侧作体外电容式透热加温，通过液晶膜感温试验和抗电磁波干扰的多点测温结果分析其热分布情况。结果：１．腔内粘膜４５℃－４８℃时，粘膜下３ｍｍ可达４９：－５０℃，体模的内腔表面５０℃时有效加温深度为０．４ｃｍ－０．５ｃｍ（２４５０ＭＨｚ），０．８ｃｍｍ－１．０ｃｍ（９１５ＭＨｚ）。８ＭＨ体外电容式透热则腔内未能达到有效治疗温度。２．对７６例腔内热疗患考观察和临床测温提示人鼻咽腔内可耐受５０℃左右，除局部微热和微痛外（停止加温即消失）．未发现不可逆的组织损害。结论：经测试和临床验证，鼻咽癌用腔内热疗法是安全有效的，有临床应用价值。purpose:InordertoimprovethedffectofradiantionfoyNPCandreducethesideeffect,thegoodwayofhyperthermiaforNPCisstudiedandsomeusefulclinicaldataandexperiencesarecollected.MaterialsandMethods:Applicatorsof2450MHzand915MHzmicrowaveintracavityprobewereseparatelyinsertedintothePhantomsandthenasopharyngealcavitiesofNPCpatientsforheatingcombinedwith8MHzexternalRFelectrodes.Liquidcristaltestingandanti-radiomulti-pointmeasuringwereusedtodelerminethedistributionoftemperature.Results:(1)Whenthetemperaturewas45℃～48℃inthesurfaceofintracavity,thetemperatureatthepointunderthemucousmembranereached49℃～50℃。Whentheintracavitysurfacetemperatureofthephantomwas50,effectivedepthis0.4cm～0.5cm(2450MHz)and0.8cm～1.0cm(915MHz).NoeffectivetreatmenttemperaturewasgotinthenasopharynxcavitybyexternalRF(8MHz)hyperthermia.(2)Observationandmeasuringtheintracavityin76patientsshowedthat50℃inhumannasopharynxcavitywaswelltoleratedexceptslighthotandpainfulfeelingwhichwoulddisapearepearedsoonafterstoppingheating.Noanyorirreversihleinjuryinnormaltissuewasfound.Conclusion:ltissafeandeffectivetotreatprimaryNPCwithintracavityhyperthermiaprovedbytemperaturemeasuringandclinicalobservation.

关 键 词：腔内辐射器 电容式透热 鼻咽癌 

分 类 号：R739.63[医药卫生—肿瘤]