偏执型精神分裂症血浆高香草酸与氟哌啶醇临床疗效的关系  

Correlationwithplasmahomovanilicacidandtheresponsetohaloperidoltreatmentinparanlidschizophren-ics

作　　者：丛中[1,2] 沈渔顿[1,2] 舒良 刘家良[1,2] 于欣 周东丰[1,2] 孙丽 管振全[1,2] 

机构地区：[1]泰山医学院精神病学教研室 [2]北京医科大学精神卫生研究所

出　　处：《中华精神科杂志》1996年第3期8-11,共4页Chinese Journal of Psychiatry

摘　　要：为了探讨偏执型精神分裂症血浆高香草酸（ｐＨＶＡ）与氟哌啶醇临床疗效的关系，对３５例偏执型精神分裂症病人以氟哌啶醇治疗６周，测定ｐＨＶＡ含量和药物浓度，并采用简明精神病评定量表、阳性症状评定量表、阴性症状评定量表进行临床评定。结果显示，与３８名正常对照者比较，全组病人及有效者的ｐＨＶＡ基础水平显著增高，治疗后ｐＨＶＡ逐步下降，阳性、阴性症状显著改善。无效者的ｐＨＶＡ基础水平与对照组无显著性差异，治疗后不下降，症状轻微改善。有效者与无效者在年龄、病期、症状严重程度及血药浓度方面无显著性差异。Toexploretherelationbetweentheplasmahomovanilicacidandtheresponsetohaloperidoltreatmentinparanoidschizophrenics,35patientswithparanoidschizophreniaenteredthestudy.Plasmaho-movanilicacid(pHVA)anddruglevelsweremeasuredatbaselineandduring6weeksofhaloperidoltreatment.PsychopathologywasweeklyevaluatedwiththeBriefPsychoticRatingScale(BPRS),theScaleforAssess-mentofPositiveSymptoms(SAPS)andtheScaleforAssessmentofNeg-ativeSymptoms(SANS).38healthycontrolswereusedforcomparisonofbaselinepHVAlevels.With-inalpatientsandthegoodresponsers,thepHVAlevelwassignificantlyhigheratbaselinethaninthecontrols,anddecreasedgradualyduringthehaloperidoltreatmentwithasignificantimprovementinbothpositiveandnegativesymptoms,whileinthepoorresponsers,thepHVAlevelatbaselinewasal-mostequaltothatinthecontrolsandnotdecreaseddur-ingthetreatment,withaslightimprovementinpositiveandnegativesymptoms.Goodresponsersandpoorre-sponsersdidnotdifersignificantlyintermsofage,durationofilness,severityofpresentingsymptoms,ordrugconcentration.Theseresultssuggestthattheremayexisttwodopaminergicsubgroupsofparanoidschizophrenia.

关 键 词：精神分裂症 高香草酸 氟哌啶醇 多巴胺 

分 类 号：R749.3[医药卫生—神经病学与精神病学]