胃癌组织中IL-17、IL-6和TGF-β1的表达及其临床意义  

Expressions and Clinical Significances of IL-17,IL-6 and TGF-β1 in Gastric Cancer Tissue

作　　者：孟欣颖[1] 马健[2] 江晨[3] 周长宏[2] 

机构地区：[1]青岛市市立医院东院区消化内科,266071 [2]青岛市市立医院东院区干保二科 [3]青岛市市立医院本部病理科

出　　处：《胃肠病学》2011年第10期593-596,共4页Chinese Journal of Gastroenterology

摘　　要：背景:胃癌是常见的消化道恶性肿瘤,慢性炎症在胃癌发生、发展中发挥作用。白细胞介素(IL)-17、IL-6、转化生长因子(TGF)-β1是重要的炎症相关因子,三者在胃癌中的作用尚不完全清楚。目的:探讨胃癌组织中IL-17、IL-6和TGF-β1的表达及其临床意义。方法:收集2009年1月-2010年1月青岛市市立医院的50例胃癌患者和26名健康对照者的组织标本,采用免疫组化染色检测IL-17、IL-6和TGF-β1的表达,并分析其与胃癌临床病理特征的关系。结果:胃癌组织中IL-17、IL-6和TGF-β1中-高强度阳性表达明显高于对照组(P<0.01)。胃癌组织中IL-17、IL-6和TGF-β1表达与临床分期、淋巴结转移均相关(P<0.05),而与患者的性别、年龄、肿瘤大小、分化程度均无关(P>0.05)。胃癌组织中IL-17表达与IL-6、TGF-β1表达呈正相关(P<0.05)。结论:IL-17、IL-6和TGF-β1在胃癌的发生和发展中可能起促进作用,IL-6和TGF-β1可能是IL-17生成的正向调节因子。Background： Gastric cancer is one of the most common gastrointestinal malignancies. Chronic inflammation is implicated in the development and progress of gastric cancer. Interleukin （IL）-17, IL-6 and transforming growth factor （TGF）-β1 are important inflammation related cytokines, but the roles of IL-17, IL-6 and TGF-β1 in gastric cancer are still unclear. Aims： To study the expressions and clinical siguificances of IL-17, IL-6 and TGF-β1 in gastric cancer tissue. Methods： Fifty patients with gastric cancer and 26 healthy controls from Jan. 2009 to Jan. 2010 at Qingdao Municipal Hospital were enrolled. The expressions of IL-17, IL-6 and TGF-β1 in gastric cancer tissue and control specimens were determined by immunohistochemistry, and their correlations with clinicopathological characteristics of gastric cancer were analyzed. Results： Compared with healthy controls, moderate to high positive expressions of IL-17, IL-6 and TGF-β31 were signicantly higher in gastric cancer tissue （P〈0.01）. Expressions of IL-17, IL-6 and TGF-β1 in gastric cancer tissue were significantly correlated with tumor stage and lymph node metastasis （P〈0.05）, but no correlation with gender, age, tumor size and degree of differentiation （P〉0.05）. Expressions of IL-6 and TGF-β1 had positive correlation with that of IL-17 in gastric cancer tissue. Conclusions： IL-17, IL-6 and TGF-β1 may have promotive effects in the development and progress of gastric cancer, and IL-6 and TGF-β1 may be the positive regulatory factors for genesis of IL-17.

关 键 词：白细胞介素17 白细胞介素6 转化生长因子Β1 胃肿瘤 免疫组织化学 

分 类 号：R735.2[医药卫生—肿瘤]