组蛋白甲基化在肿瘤低氧反应中的作用  

Role of Histone Methylation in Hypoxic Response of Tumor

作　　者：陈丽莎[1] 傅琳娜[1] 陈萦晅[1] 

机构地区：[1]上海交通大学医学院附属仁济医院消化内科上海市消化疾病研究所,200001

出　　处：《胃肠病学》2011年第10期628-631,共4页Chinese Journal of Gastroenterology

基　　金：国家自然科学基金项目(81172321)资助

摘　　要：多数实体肿瘤内存在低氧甚至无氧区,细胞对低氧的反应主要受低氧诱导因子(HIF)调节。表观遗传在低氧反应中发挥核心作用,而组蛋白甲基化是表观遗传修饰的方式之一,组蛋白去甲基化酶的发现证实组蛋白甲基化修饰是一个可逆过程。JMJD家族是一类重要的组蛋白去甲基化酶,低氧通过上调部分JMJD蛋白,调节特定靶基因的表达,从而促进肿瘤的发生、发展,这为肿瘤治疗提供了潜在的新靶点。Hypoxia even anaerobic zone exists in most solid tumors. Cellular response to hypoxia is predominantly regulated by hypoxia-inducible factor （HIF）. Epigenetics is at the center of hypoxic response, and histone methylation is one of the forms of epigenetic modifications. The discovery of histone demethylases reveals that histone methylation is reversible. The JMJD family is one of the most important histone demethylases. Hypoxia up-regulates part of the JMJD proteins, which regulates the expression of specific target gene and promotes the genesis and progress of tumor, and this may provide a potential new target for cancer therapy.

关 键 词：缺氧 缺氧诱导因子1 组蛋白去甲基化酶 JMJD家族 肿瘤 

分 类 号：R730.2[医药卫生—肿瘤]