THERAPEUTIC EFFECT OF CYPROHEPTADINE ON TRAUMATIC BRAIN EDEMA IN RATS  

作　　者：吕键 杨庆余 王美纳 梁健 康爱群 

出　　处：《Journal of Pharmaceutical Analysis》1996年第2期146-150,共5页药物分析学报（英文版）

摘　　要：Acute traumatic brain edema models were established in SD rats by dropping weight methods.We observed the therapeutic effect of Cyproheptadine(Cyp)on traumatic brain edema.It was shown that Cyp could obviously reduce the brain water content,decrease the releae or LDH,reduce the seventy of the pathological changes at the injury areas,increase the SOD activity and decrease the production of MDA in SD rats.The results suggest that Cyp has obvious.therapeutic effect on traumatic brain edema.The mechanism may be that it can increase the activity or clearance enzyme of free radical,inhibit lipid peroxldation and reduce intracellular Ca2+-overload.Acute traumatic brain edema models were established in SD rats by dropping weight methods.We observed the therapeutic effect of Cyproheptadine(Cyp)on traumatic brain edema.It was shown that Cyp could obviously reduce the brain water content,decrease the releae or LDH,reduce the seventy of the pathological changes at the injury areas,increase the SOD activity and decrease the production of MDA in SD rats.The results suggest that Cyp has obvious.therapeutic effect on traumatic brain edema.The mechanism may be that it can increase the activity or clearance enzyme of free radical,inhibit lipid peroxldation and reduce intracellular Ca2+-overload.

关 键 词：CYPROHEPTADINE traumsatic brain edema lipid peroxide 

分 类 号：R971[医药卫生—药品]