肺癌患者血清对正常人自然杀伤细胞活性抑制性影响的研究  

THE INHIBITORY EFFECT OF SERUM FROM PATIENTS WITH LUNG CANCER ON THE CYTOTOXIC ACTIVITY OF NK CELLS

作　　者：陈琼[1] 丘万服[1] 海镇环[1] 

机构地区：[1]湖南医科大学附属湘雅医院呼吸研究室

出　　处：《中国现代医学杂志》1995年第3期12-13,19+78,共4页China Journal of Modern Medicine

摘　　要：探讨肺癌患者血清对正常人ＮＫ细胞杀伤活性的影响，同时检测患者血清ｓＩＬ─２Ｒ的水平。结果显示：患者血清可使正常人外周血ＮＫ细胞杀伤活性明显降低，血清中ｓＩＬ─２Ｒ水平较对照组明显升高，其升高的程度与ＮＫ细胞杀伤活性的降低相关，这些提示肺癌患者血清中存在免疫抑制物质，高水平的ｓＩＬ─２Ｒ可能是一种主要的免疫抑制因子。The effect of the serum on the cytotoxic activity of NK cells and the serum levels of SIL-2R were detected in 20 patients with lung cancer,20 normal controls.The serum of patients appeared to have inhibitory action on the cytotoxic activity of NK cells of normal individuals, the serum levels of SIL-2R were significantly higer in patients than those in normal controls.The augmentation of SIL-2R in the serum of patients correlated with the decrease of the cytotoxic activity of NK cells of the normal individuals treated by the serum of patients.These suggested that are innumosuppressive factors in the serum of patients and the elevated levels of SIL-2R may play an important role in immunosuppression.

关 键 词：肺癌 自然杀伤细胞 可溶性白细胞介素2受体 免疫抑制 

分 类 号：R734.203[医药卫生—肿瘤]