阿霉素羧甲基化葡聚糖微球肝动脉化疗性栓塞治疗肝癌的实验研究与临床初步应用  

Study of Hepatocellular Carcinoma(HCC)Treated withAdriamycin Carboxymethydextran Microsphere Tran-scatheter Arterical Chemoembolization an Experiment andCIinical observation

作　　者：王世德 谢敬霞[1] 李选[1] 王田力[1] 何素梅[1] 魏树礼[1] 

机构地区：[1]广州孙逸仙心血管医院影像科,北京医科大学附三医院放射科,北京医科大学药学药理教研室

出　　处：《中华肿瘤防治杂志》1995年第3期176-179,共4页Chinese Journal of Cancer Prevention and Treatment

摘　　要：本实验对国内首次合成的阿霉素羧甲基化葡聚糖微球（ＡＤＭ─ＣＭ─ＤＭＳ）进行系统的体外特性分析、人体内药代动力学特征、犬肝动脉栓塞效果的实验研究及临床初步应用。结果表明：ＡＤＭ─ＣＭ─ＤＭＳ具有使用方便、性能稳定、不聚块、不碎裂的特点；能缓慢释放ＡＤＭ而持续有效的提高靶区药物浓度，延长局部作用时间，减少全身毒副作用；追踪观察１６周犬被栓塞之肝动脉未见再通及侧枝循环形成，其栓塞作用是显著而持久的；临床初步应用治疗五例肝癌患者未发现副作用，短期追踪疗效显著。e first synthesized ADM─CM─ DMS(55～ 105um in diameter)containing ADM 30%w/w,The characteristicsof ADM─CM ─DMS in vitro and the characteristics of the phamacokinetics and embolic effect of ADM─CM─DMSin vivo were studide.The result demonstrated that ADM─CM─DMS were easier to use and did not shatter with agi-tated and permanent.ADM─CM─DMS could release ADM slowly,and prolong local target effect in liver,reducesystemic exposure to the antineoplastic agent,maintain intrahepatic drug level. Following-up angigraphic and patholog-ic results revealed that the embolic effect of ADM─CM─DMS was obvious and sustained.The blocked peripheral ves-seles did not recanalized in 16 weeks and no by-pass vesseles could be observed.5 cases with HCC were treated bytranscatheter arterial chemoembolization, no side effect could be observed,the effect of ADM─CM─DMS was obvi-ous in three months.

关 键 词：阿霉素羧甲基化葡聚糖微球 化疗性栓塞 药代动力学 肝癌 

分 类 号：R735.7[医药卫生—肿瘤]