晚期卵巢癌的化疗  

The chemotherapy for advanced ovarian carcioma

作　　者：张晓春[1] 刘德华 史绍山 

机构地区：[1]山东省肿瘤防治研究院,胶州市中医院,莱西市人民医院

出　　处：《中华肿瘤防治杂志》1995年第3期197-199,共3页Chinese Journal of Cancer Prevention and Treatment

摘　　要：以８４例晚期卵巢癌患者采用顺铂或卡铂为主的联合化疗方案行全身化疗或腹腔化疗。卡铂用药组总有效率为５５．６％，一年生存率为７７．３％；顺铂用药组总有效率为５６．４％，一年生存率为９０％。卡铂组胃肠反应较顺铂组轻，血液毒性较顺铂重。未研究结果表明：卡铂尚不能常规替代顺铂治疗卵巢癌，顺铂腹腔化疗可作为晚期卵巢癌和复发卵巢癌的首选治疗。4 patients with advanced ovarian cancer had been treated in our hospital,45 patients were treated by CP─con-taining regimens,24 patients were administered by the intraperitoneal route(IP)with CF(CP + 5─Fu),21 by in-traverous infusion (IV)with CVC(CP+VCR+CTX),39 patient were treated by DDP─ containing regimens,22 byIP with PF(DDP+5─Fu),13 by IV with PVC(DDP+VCR+CTX),The response rate was 55. 6%for CP contain-ing regimens and 56.4%for DDP containing regimens.Gastrointestinal reaction and renal toxicity were less severe inCP containing regimens than DDP containing regimens.However CP had more marked myelosuppessive effect.

关 键 词：卡铂 顺铂 卵巢恶性肿瘤 

分 类 号：R735.31[医药卫生—肿瘤]