高危人群中筛检发现的肝癌临床分析  

Clinic Study of Primary Hepatic CancerDetected by Screening in High Risk Population

作　　者：张宝初[1] 王墨荣[1] 陈建国[1] 姜元辉[1] 陈启光[1] 恽振先[1] 沈其君[1] 

机构地区：[1]南京铁道医学院

出　　处：《中华肿瘤防治杂志》1995年第2期105-106,98,共3页Chinese Journal of Cancer Prevention and Treatment

摘　　要：本文分析应用ＡＦＰ和／或Ｂ超筛检发现的原发性肝癌２９８例。资料表明，ＡＦＰ≤５０ｍｇ／Ｌ的ＰＨＣ依赖Ｂ超发现，ＡＦＰ５１～４００ｍｇ／Ｌ的ＰＨＣ依赖ＡＦＰ与Ｂ超筛检而诊断，两者合计占３ｌ．２％，显示Ｂ超基本解决ＡＦＰ低水平或阴性肝癌的诊断问题。高危险肝癌人群筛检可发现近４／５（７９．５％）为早期肝癌。晚期肝癌仅占２％，其ＡＬＴ、ＡＬＰ、ｒＧＴ、胸透、Ｂ超的阳性率较低，而单个癌结节、门脉无癌栓小肝癌发现率手术探查率。切除率及生存率较高。高危险人群中进行筛检具有经济、实用、有效、具有积极的临床意义。不失为肝癌早期发现Ⅱ级预防的有效途径之一。1985 to Jun. 1993,298 cases with Primary Hepatic Cancer(PHC)were detected by screening in highrisk population. The age was ranged from 23 to 76 years with a median 44.The sex ratio of male to female was 4.2:1. 183(61.4%)patients had pathological diagnosis.Among 198 cases, 62 cases(20. 8%)with negative alpha-feto-protein (AFP<50ug/L)were detected by B-ultrasonography(BUS),31 cases(10.4%)with low level of AFP(5/-100ug/L )were detected by AFP and BUS.237 cases(79.5%)out of 298 were subclinical hepatic cancinoma. 211cases(70.8%)with small PHC whose gumor size was equal to or less than 5cm in diameter were diagnosed by opcra-tion, BUS,CT and hepatic angiogrpahy. The resection rate was 71.2%,The l and 3 years survival rate were 73.7%and 24.5%respcctively. Baded on the result of analysis of 298 PHC casL,it may be concluded that screening in highrisk population using AFP and BUS are important measurements of secondary prevention of PHC.

关 键 词：原发性肝癌 高危险人群筛检 

分 类 号：R735.7[医药卫生—肿瘤]