表皮生长因子受体在肝癌中的表达及其临床意义  

Clinical Significance Of The Expidermal Growh Factor Receptor In Hepatocellular Carcinoma

作　　者：王效民[1] 汤钊猷[1] 邹合强[1] 鲍卫华[1] 

机构地区：[1]上海医科大学肝癌研究所

出　　处：《中华肿瘤防治杂志》1995年第1期22-24,共3页Chinese Journal of Cancer Prevention and Treatment

摘　　要：对５１例肝癌标本进行的免疫组织化学分析显示，４７％的标本肿瘤细胞中有表皮生长因子受体（ＥＧＦＲ）表达。根据ＥＧＦＲ在肿瘤中的表达情况将病例分为两组，ＥＧＦＲ阳性组和ＥＧＦＲ阴性组。ＥＧＦＲ阳性组的肿瘤体积和术后复发率均高于ＥＧＦＲ阴性组（Ｐ＜０．０５）。两组的肿瘤分化程度无显著性差异。Imrnunohistochemical aassav was conducted in 51 specimens of hepatocellular carcinoma(HCC ),The resultsdemonstrated that EGFR expression was found in 47 pereent HCC tumors;According to the statusof EGFR inHCC tumors,the pateints were divided into two groups, EGFR positive and EGFR negative,The tumor size andrecurrent rate in EGFR positive pateints was significantly higher than that in EGFR negaative patints(P<0.05 ).No significant difference in histopathologic grade was found between two groups.The resuIts suggest that the ex-oression of EGFR in HCC is relaated to the tumor growth and the prognosis of HCC pateints.

关 键 词：表皮生长因子受体 肝细胞型肝癌 

分 类 号：R735.7[医药卫生—肿瘤]