白血病大鼠化疗后血液中集落刺激因子、造血干细胞和残留白血病细胞动态观察  

OBSERVATION ON DYNAMIC CHANGE OF COLONY STIMULATING FACTOR, HEMATOPOIETIC STEM CELLS AND RESIDUAL LEUKEMIC CELLS IN PERIPHERAL BLOOD OF LEUKEMIC RAT AFTER CHEMOTHERAPY

作　　者：赵钧铭[1] 应红光[1] 王淑萍[1] 褚建新[1] 

机构地区：[1]中国医学科学院中国协和医科大学血液学研究所,天津300020

出　　处：《中国实验血液学杂志》1995年第2期196-199,共4页Journal of Experimental Hematology

基　　金：卫生部科研课题

摘　　要：动态观察了白血病大鼠大剂量化疗后血液中血清集落刺激因子(CSF)、造血干细胞(HSC)和残留白血病细胞的变化。研究结果证明,白血病化疗后血清CSF最早出现,然后HSC增殖并向周围血液迁移,接着周围血细胞开始恢复,血液中白血病细胞出现最晚。随着血液中白血病细胞的增加,正常血细胞随之下降。揭示正常造血细胞与白血病细胞相互竞争而消长的规律,无疑有助于我们了解白血病复发的机理。The study dynamically observed the changes of colony stimulating factor (CSF), hematopoietic stem cells (HSC) and residual leukemic cells in peripheral blood of leukemic rats after chemotherapy. The results demonstrated that serum CSF began to increase on day 4 after chemotherapy and reached its highest value on day 7 and then reduced gradually. Meanwhile, the (HSC) proliferated and migrated to peripheral blood, and reached its peak on day 7, being about 16% of blood mononuclear cells, and then decreased. The picture of peripheral blood began to recover and reached normal value about day 18. Leukemic cells could not be detected in blood until day 14 after chemotherapy. Normal blood cells were decreased while leukemic cells increased. It appears that there are keen competition between leukemic cells and normal cells in leukemia. After high dose chemotherapy leukemic cells were inhibited severely, therefore it was to favor hematopoietic recovery. The recovery procedure of hematopoiesis seems to follow this pattern: serum CSF was early increased, and then, the hematopoietic stem cells proliferated and migrated to blood, blood picture began to recover, at last leukemic cells appeared in blood. Discovering this pattern of hematopoietic recovery helps to clear mechanism of leukemia relapse.

关 键 词：白血病 化学疗法 集落刺激因子 造血干细胞 残留白血病细胞 

分 类 号：R733.7[医药卫生—肿瘤]