重症肌无力免疫病原学研究Ⅰ重症肌无力患者血清免疫学研究  

The Studies on Immunoetiology of Myasthenia GravisⅠ.A Study on Seroimmunology of the Patlents with Myasthenia Gravis

作　　者：高波廷[1] 杨明山[1] 刘锡民[1] 徐金枝[1] 曹学兵[1] 

机构地区：[1]同济医科大学附属同济医院神经科

出　　处：《卒中与神经疾病》1995年第2期68-72,共5页Stroke and Nervous Diseases

摘　　要：本文用ＥＬＩＳＡ法同步、动态地观测了２８５例ＭＧ患者血清ＡｃｈＲａｂ、ＰｓＭａｂ和ＣＡＥａｂ的变化。实验结果表明ＭＧ患者体内增高的ＡｃｈＲａｂ是ＭＧ发病的主要体液因素。部分血清ＡｃｈＲａｂ阴性ＭＧ患者（１７．５％）的发病可能与血清ＰｓＭａｂ异常有关。另一部分血清ＡｃｈＲａｂ和ＰｓＭａｂ均异常的ＭＧ患者（１２．６％）则可能同时存在骨骼肌神经肌肉接头突触前和突触后的损害。血清ＣＡＥａｂ测定在辅助诊断胸腺瘤方面具有高度的灵敏度和特异性，可作为临床早期诊断胸腺瘤的过筛检查。In this paper,acetylcholine receptor antibody(AchRab),Pre-synaltic membrane an tibody(PsMab),and thymoma-associated antibody or citric acid estract antibody(CAEab)in sera of 285 patients with myasthenia gravis(MG)were dynamically detected with ELISA.The results showed that the increased seral AchRab might be a major factor in pathogenesis of MG.For the kind of seronegative MG patients(17.5%),seral PsMab may play an improtant role in etiology and patho genesis of MG,There may be both post-synaptic and pre-synaptic damages in the patients(12.6%) whose seral AchRab and PsMab titers are increased.The detection of serum CAEab with ELISA possesses high sensitivity and specificity in discovering thymoma.This serological assay can be looked as a screen test for diagnosing thymoma early in neurological bedside.

关 键 词：重症肌无力 乙酰胆碱受体抗体 突触前膜抗体 胸腺瘤相关抗体 发病机理 

分 类 号：R746.1[医药卫生—神经病学与精神病学]