恶性肿瘤患者放疗后胞质分裂阻断的淋巴细胞微核率的变化  

MICRONUCLEI IN CYTOKINESIS-BLOCKED LYMPHOCYTES OF CANCER PATIENTS AFTEER ADIOTHEEAPY

作　　者：任力飒[1] 王鹤[1] 杨建平[1] 牛玉中[1] 张鸿翔[1] 

机构地区：[1]山西省肿瘤研究所,山西省肿瘤医院

出　　处：《中华放射肿瘤学杂志》1994年第2期127-129,148,共4页Chinese Journal of Radiation Oncology

摘　　要：我们采用胞质分裂附断微核法对１８例肿瘤放疗患者的淋巴细胞微核进行了检测分析。其中食管癌８例、肺癌４例、乳腺癌３例，其它肿瘤３例。微核检测分三次，即放疗前累积剂量达到３０Ｇｙ和６０Ｇｙ时。结果显示患者的平均微核率分别为１５．６±６．６‰、６５．１±１９．０‰、１２２．６±３５．８‰。所有患者血淋巴细胞微核率与照射剂量之间呈良好的线性关系。接受同等剂量照射的三组患者其组间微核率无明显差异。Abstract A study on micronucleus(MN) induction assay for 18 cancer patients followingradiotherapy by using cytokinesis-block micronucleus method was performed in 8esophageal cancers, 4 lung cancers, 3 breast cancers and 3 other cancers.Lymphocytes of the patients were analysed for MN frequency just before theradiotherapy, at 30Gy and 60Gy. The results showed that the mean frequencies(micronucleated binucleate cells in binucleated cells)were 15.6± 6.6‰, 65.1±19.0‰,122.6± 35.8‰at the doses of 0Gy, 30Gy and 60Gy, respectively. There were a linearrelationship between the radiation doses and the MN frequencies in all the patients.However, there was no significant difference among the MN frequencies of variousgroups of the patients who received the same radiation doses.

关 键 词：恶性肿瘤患者 ￣(60)Co放疗 CBMN法 剂量效应关系 

分 类 号：R730.55[医药卫生—肿瘤]