家兔动脉粥样硬化病变内p53基因的实验研究  

STUDY OF P53 IN ATHEROSCLEROTIC PLAQUES

作　　者：杨和平[1] 傅爱华[1] 姚阿卿 杨亚东[1] 张晨辉[1] 周洪[1] 陈伯荣[1] 汤健[1] 周爱儒[1] 

机构地区：[1]北京医科大学心血管基础研究所

出　　处：《北京大学学报（医学版）》1994年第S1期77-79,共3页Journal of Peking University:Health Sciences

摘　　要：对家兔行高脂、高胆固醇膳食和内皮细胞剥脱，对斑块组织泡沫细胞进行了ｐ５３免疫组化和分子杂交研究。结果显示，泡沫细胞有ｐ５３基因的突变和低表达。这些变化可能与动脉粥样硬化的细胞异常增殖有关。The methylation and expression of p53 were studied.in atherosclerotic plaques. Atherosclerosis was initi-ated in 2.5-3.0 kg New Zealand white rabbits by feeding cholesterol,oil and endothelial debridement of theaorta。There were the methylation of the partial CCGG sites,low levels of expression of the wild-type p53and mutant p53 protein in the plaques。These might be an important cause of the cellular proliferation duringdevelopment of atherosclerosis。

关 键 词：动脉粥样硬化 基因表达 P53 

分 类 号：R394.3[医药卫生—医学遗传学]