hypotensive effedts and mechansms of adrenomedullin(13─52)  

HYPOTENSIVE EFFECTS AND MECHANISMS OF ADRENOMEDULLIN(13-52)

作　　者：田青 赵东 谭敦勇 赵云涛 汤健 张肇康 

出　　处：《北京大学学报（医学版）》1994年第S1期162-172,共11页Journal of Peking University:Health Sciences

摘　　要：ＨＹＰＯＴＥＮＳＩＶＥＥＦＦＥＣＴＳＡＮＤＭＥＣＨＡＮＩＳＭＳＯＦＡＤＲＥＮＯＭＥＤＵＬＬＩＮ（１３－５２）ＴｉａｎＱｉｎｇ田青，ＺｈａｏＤｏｎｇ赵东，ＴａｎＤｕｎｙｏｎｇ谭敦勇，ＺｈａｏＹｕｎｔａｏ赵云涛，ＴａｎｇＪｉａｎ汤健，ＣｈａｎｇＪａｗＫａ...nstitute of Cardiovascular Research,Beijing Medical University Peninsula Laboratories Inc. Belmont, California 94002 USA Abstract Adrenomedullin(AdM)is a newly isolated peptide with hypotensive activity in nor-motensive rat.Nothing was known regarding its role on hypertensive animals.This paper showed that AdM could reduce blood pressure in a manner of dose-depencence and its hypotensive effect on spontaneously hypertensive rat and renal hypertensive rat was more potent than that on nor- motensive rats.An antagonist for calcitonin gene related peptide(CGRP)had no influence on the effect of AdM but significantly inhibited the depressive effect of CGRP on blood pressure of hyper-tensive rat,suggesting that the hypotensive mechanism of AdM was not through the function of CGRP.AdM could markedly inhibit endothelin and angiotension Ⅱ release from aortic artery and dilate this blood vessel.The dilator effect of AdM was completely abolished by blocking the pro-duction of nitric oxide(NO)and partially decreased by inhibiting the production of prostacyclin (PGI2).Our studies suggest that (1) AdM is possibly a newly found anti-hypertensive peptide dif-ferent from CGRP;(2)its hypotensive mechanism could be related to inhibition of endothelin and angiotensin Ⅱ release and(3)its vasodilator role depends on NO and/or PGI2.

关 键 词：ADRENOMEDULLIN CALCITONIN gene related peptide ENDOTHELIN Angiotensin Ⅱ NITRIC oxide PROSTACYCLIN Hypertension 

分 类 号：R541.3[医药卫生—心血管疾病]