适应性细胞保护作用──弱刺激剂预防胃损伤和缺血是通过前列腺介导的  

ADAPTIVE CYTOPROTECTION-MILD IRRITANT PROVENT GASTRIC ISCHEMIA AND DAMAGE THROUGH PROSTAGLANDIN AS A MEDIATOR

作　　者：陈宝雯[1] 林兆鑫[1] 曹之宪 许伟武 陆照棠 

机构地区：[1]北京医科大学第一医院,香港大学

出　　处：《中华消化杂志》1994年第S1期26-29,共4页Chinese Journal of Digestion

摘　　要：观察自体有效物质前列腺素（ＰＧｓ），对基础血流和限制胃粘膜血流（ＧＭＢＦ）供应后修复的影响，及其抑素（消炎痛）对它的逆转作用。结果显示：（１）在胃粘膜表面预先给予一种刺激剂，可预防随后给予的损伤剂，表明细胞具有适应性保护作用；（２）维持正常的ＧＭＢＦ，可能是通过内源性ＰＧｓ的调控；（３）消炎痛既是自体有效物质的抑制剂又是致溃疡剂，其作用可能是抑制内源性ＰＧｓ的合成；（４）组织损伤后ＧＭＢＦ的恢复，可能通过内源性ＰＧｓ的调节以及它们的化合物在溃疡治愈中的作用。结论：适应性细胞保护作用是通过内源性ＰＧｓ介导的。The present study was designed to demonstrate the role of this autocoid in the basal gastric mucosal blood flow (GMBF)and the restoration of blood flow after restrication of blood flow to the stomach and then its chalonic autocoid (indomethacin) reversed their action. The results showed that application of an irritant to the surface of the gastric mucosa confers pretection against subsequent application of a damaging agent(adaptive cytoprotection). The maintenance of a normal GMBF is probably controlled by endogenous PGs. Indomethacin was not only a chalonic autocoid but also anulcerogen, it may operate on PGs synthesis inhibition, The restoration of GMBF after tissue damage is probably controlled by endogenous PGs and these compounds could play an important role in ulcer healing.Conclusion is adaptive cytoprotection by endogenous PGs as a mediator of this phenomenon.

关 键 词：前列腺素 消炎痛 胃粘膜损伤 适应性细胞保护作用 胃粘膜血流 

分 类 号：R364[医药卫生—病理学]