与胆石形成有关的肝胆管局部病理变化  

Pathological Changes of the Intrahepatic Biliary Tree Related to Gallstone Formation

作　　者：陈燕凌[1] 殷凤峙[1] 陈碧芬[1] 

机构地区：[1]福建医学院附属协和医院普外科,福建医学院病理解剖学教研室

出　　处：《福建医科大学学报》1994年第3期239-241,共3页Journal of Fujian Medical University

摘　　要：观察１００例肝胆管结石病患者肝胆管病理结构及粘液分泌的改变，发现肝胆管附属腺增生、胆管上皮乳头状增生、胆管纤维化及狭窄、胆管壁慢性炎性细胞浸润等是肝胆管结石病时肝胆管突出的病理改变，与胆石的形成及发展有密切关系。Resected liver specimens from 100 cases of hepatolithiasis were examined for the pathological changes and mucus secretion of the intrahepatic biliary tree. The typical changes of intrahepatic bile ducts in hepatolithiasis were marked hyproliferation of the peribiliary glands,papillary hyperplasia of surfacelining epithelia, and fibrosis of the bile duct wall.These changes may derive from cholangitis and become a prerequisite for the early stage gallstone formation. In addition, we found profound lymphocytes infiltration within the glandular structures, which suggested a persistent inflammation in bile duct wall. As it has been comfirmed that the bacteria of bile can act as a“connective factor”in linking the glycoprotein and bilirubin, the mucus containing large quantity of bacteria may play a dominant role in nucleation of gallstone.

关 键 词：肝胆管结石 病理改变 粘液组化 

分 类 号：R575.7[医药卫生—消化系统]