重症肌无力的临床分型、电诊断及乙酰胆碱受体抗体的比较  

Comparative Analysis of Clinical Classification, Electrodiagnosis and Antibody Titre of Acetylcholine Receptor in Myasthenia Gravis

作　　者：崔丽英[1] 汤晓芙[1] 许贤豪[1] 刘南平 李本红[1] 杜华[1] 

机构地区：[1]北京协和医院神经科,宁夏医学院附属医院脑电图室

出　　处：《卒中与神经疾病》1994年第2期65-67,共3页Stroke and Nervous Diseases

摘　　要：本文对３９８例重症肌无力（ＭＧ）患者的临床分型、重复电刺激（ＲＮＳ）及血中乙酰胆碱受体抗体（ＡｃｈＲ·Ａｂ）浓度三者作了比较分析。其中眼肌型２２４例，全身型１６１例，肌无力危象１３例。ＲＮＳ总的阳性率５１．３％，其中刺激腋神经时最高（６８．４％）。全身型者ＲＮＳ阳性率明显高于眼肌型。对临床眼肌型，ＲＮＳ可能发现亚临床病变，有助于预后的估计。ＲＮＳ异常与ＡｃｈＲ·Ａｂ浓度升高有相关性（Ｐ＜０．０５），对于ＭＧ的诊断，两者的结果具有互补性，其中ＲＮＳ异常而ＡｃｈＲ·Ａｂ正常者占２１．５％，相反的情况占２０．５％。patients with myasthenia gravis(MG)were analyzed through clinical classification,repetitive nerve stimulation(RNS)and blood concentration of antibodies to the acetylcholine receptor(AchR·Ab),including 224 with ocular myasthenia,161 with generalized one and 13 with myasthenic crisis. The total abnormality rate of RNS was 51.3%,among which the abnormality with the axillary nerve stimulated was the highest (68.4%).The patients with generalized MG had markedly higher RNS abnormality rate than that with ocular myasthenia,but the determination of RNS may be of significance in detecting the sub-clinical lesion and evaluating the prognosis to ocular myasthenia clinically.The fact that there was well correlation between the results of RNS and AchR·Ab suggested that the two investigating methods had reciprocal effect,in which the patients with abnormal RNS and with normal AchR·Ab accounted for 21.5%,whereas those with normal RNS and abnormal AchR·Ab for 20.5%.

关 键 词：重症肌无力 电诊断 乙酰胆碱受体抗体 

分 类 号：R746.1[医药卫生—神经病学与精神病学]