6-硝基化合物对小鼠小肠隐窝上皮细胞增敏作用的研究  

A RADIOSENSITIZING EFFECT OF 6-NITRO COMPOUNDS (NO Ⅱ) ON INTESTINAL CRYPT STEM CELLS IN MICE

作　　者：杨伟志[1] 沈瑜[1] 糜福顺[1] 邓津生 董秀钥[1] 王京红[1] 

机构地区：[1]中国医学科学院肿瘤医院,100021

出　　处：《中华放射肿瘤学杂志》1993年第1期49-50,76,共3页Chinese Journal of Radiation Oncology

摘　　要：6-硝基化合物是中国医学科学院放射研究所研制的系列增敏剂中的一种。我室经体内外两步实验筛选,认为6-硝基化合物是较为理想的肿瘤细胞增敏剂。我们观察了Ⅱ号药对小鼠小肠隐窝上皮细胞的增敏作用。结果显示:SER=1.04,增敏比明显低于Ⅱ号药对肿瘤细胞的增敏比。表明Ⅱ号药对小鼠小肠隐窝上皮细胞无明显增敏作用,是一种有希望的值得继续探索完善的含氧细胞增敏剂。6- Nitroindazele (DEAENT), a chemical compound supplied by Radiology Institute , Chinese A-cademy of Medical Sciences, has been proved to have radiosensitizing effect both in vitro and in vivo. In this paper, the effect of this drug on intestinal crypt cells was studied. The SER of DEAENT for intestinal crypt cells was 1. 04, which was significantly less than SER on tumor cells. This further proves DEAENT has high potential as a radiosensitizer clinically.

关 键 词：6-硝基化合物 乏氧细胞增敏剂 动物实验 

分 类 号：R73[医药卫生—肿瘤]