Ⅱ期乳癌术后放疗的作用  

POSTOPERATIVE RADIOTHERAPY FOR STAGE Ⅱ BREAST CANCER

作　　者：徐博[1] 申文江 李庆琪 

机构地区：[1]北京市肿瘤防治研究所,100034

出　　处：《中华放射肿瘤学杂志》1993年第3期40-42,70,共4页Chinese Journal of Radiation Oncology

摘　　要：1976～1982年对93例Ⅱ期乳癌行根治术后放疗D_T40～45Gy/4～5周。同期行单纯手术172例。术后放疗与单纯手术组的10年生存率分别是69.9％和73.3％,无统计学差异。但对于腋淋巴结转移1～3个组,术后放疗和单纯手术的10年生存率为91.7％和58.3％(P<0.01),两组10年局部复发为0％和12.5％(P<0.05),术后放疗组同侧锁骨上区复发为3.2％,单纯手术为8.1％(P<0.05),说明术后放疗对腋淋巴转移1～3个的患者,可以减少复发提高生存率。腋淋巴结转移≥4个组,术后放疗45Gy局部控制率和远期生存率皆未见改善。From 1976 to 1982. 93 female patients with pathologically proved stage Ⅱ breast cnacer were first treated by radical mastectomy and then given postoperative radiation therapy (RM + RT). 172 similar patients served as control (RT) . Radiation therapy of 40-45 Gy/4-4. 5 wk was delivered to the appropriate lymphatic drainge regions and the chest wall. All were followed for more than 10 years. The 10- year survival rates in these two groups were 69. 9% and 73. 3% (P>0. 05). Yet, those who had 1-3 positive axillary lymphnodes gave 10- year survivals of 91. 7% (RM + RT) and 58. 3% (RT only) (P<0. 01). The local 10- year recurrence rates were 0 and 12. 5% (P<0. 05), and the recurrence in the supraclavicular area was 3. 2% in the RM + RTgroup and 8. 1% in the RT group. (P<0. 05). However, for patients with ≥ 4 positive axillary lymph nodes, postoperative raditherapy did not improve the long term survival nor could it reduce the local recurrence. The authors believe that postoperative radiotherapy could improve the 10- year survival rates, reduce the local recurrence and the relapse in the supraclavicular area in stage Ⅱ breast cnacer with < 4 positive axillary lymph nodes.

关 键 词：乳癌 放疗 手术 

分 类 号：R73[医药卫生—肿瘤]