放射治疗对鼻咽癌患者外周血T淋巴细胞亚群分布影响及预后  

EFFECTS OF RADIOTHERAPY FOR T LYMPHOCYTE SUBSETS FROM PERIPHERAL BLOOD OF PATIENTS WITH NASOPHARYNGEAL CANCER AND PROGNOSIS

作　　者：周决[1] 曹世龙 邱杏仙 李焕荣 沈瑾 张凤坤 仉洪珍 胡长坤 

机构地区：[1]上海医科大学肿瘤医院,200032

出　　处：《中华放射肿瘤学杂志》1993年第4期24-26,80,共4页Chinese Journal of Radiation Oncology

摘　　要：1990年1月至12月应用流式细胞仪和T细胞单克隆抗体检测了40例鼻咽癌患者在放疗前,放疗结束时,放疗结束后2个月及1年时外周血T细胞亚群的分布。结果表明,放疗前鼻咽癌患者总T细胞明显低于正常人(P<0.01),T_4(辅助/诱导)细胞百分比明显下降(P<0.001),T_8(抑制/细胞毒)细胞百分比上升。T_4/T_8比值在晚期病人中显著倒置。放疗前后总T细胞变化不大。T_4/T_8比值继续下降,放疗后2月最为明显。放疗后1年T_4/T_8比值开始上升,但仍然低于放疗前。作者发现,鼻咽癌患者放疗前和放疗后1年的T_4/T_8比值与预后呈现一定的关系。T lymphocyte subsets from peripheral blood of cases with nasopharyngeal cancer were counted before and at different intervals after radiotherapy using monoclonal antibodies in connection with flow cytometry. Significant deficits were found in the percentage of pan T cell, T4 cell and T4/ T8 ratio before the treatment. Very significant decrease of T4/T8 ratio after radiotherapy was observed in comparison with the pretreatment finding. T4/T8 ratio obtained at 12 months after radiotheapy was still lower than that of pretreatment. Distinct difference in patterns of T cell subsets distribution were observed in comparison between patients who were disease free and those with recurrence during the 12 month observation. The significant lower value of the T4 cell percentage and T4/T8 ratio before treatment and 12 months after radiotherapy were related to the tumor recurrence.

关 键 词：鼻咽癌 T细胞亚群 流式细胞仪 

分 类 号：R73[医药卫生—肿瘤]