Glutathione S-Transferase Isoenzymes as Marker in Preneoplasia of Rat Chemical Hepatocarcinogenesis  

作　　者：左瑾 方福德 丁濂 谢大英 

机构地区：[1]Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing 100005 PRC [2]Institute of Occupational Medicine, Chinese Academy of Preventive Medicine, Beijing 100050 PRC

出　　处：《Chinese Science Bulletin》1993年第7期602-607,共6页

基　　金：Project supported by the National Natural Science Foundation of China

摘　　要：It has been generally accepted that about 85％ of cancers are caused by chemical factors and the chemically induced carcinogenic process can be divided into two or three stages, i. e. initiation and promotion, or together with further progression. The initiation is usually considered to be an irreversible process, but it can be blocked to further progress to cancer. For this reason, searching of objective markers for identifying initiated cells has played an important role in defining the preneoplastic lesion. So far, a large number of studies have been carried out on this object, including biochemistry, histopathology, histochemistry, immunohistochemistry, etc., and nearly thirty histochemical and other phenotypic changes have been found associated with the putative preneoplastic liver

关 键 词：GST-isoenzyme chemicai HEPATOCARCINOGENESIS isoelectric focusing MARKER enzyme. 

分 类 号：N[自然科学总论]