Study on pulmonary injury due to acute H_2S inhalation and its therapeutic scheme  

作　　者：欧阳子倩 余争平 刘勇 

机构地区：[1]Department of Toxicology,Third Military Medical College,Chongqing,630038

出　　处：《Journal of Medical Colleges of PLA(China)》1993年第3期308-314,共7页中国人民解放军军医大学学报（英文版）

摘　　要：Pulmonary injury after acute H₂S inhalation was studied with bronchoalveolar lavage（BAL）,ultracentrifuge,and optical and electron microscopy.The changes of the activities oflactate dehydrogenase,alkaline and acid phosphatase,and angiotension converting enzymes inBAL fluid were used as the indicator of cellular damages,those of leucocytic count and the indi-cator of inflammatory response,and those of the concentration of protein and Evans blue as theindicator of vascular permeability.In addition the effects of H₂S on lipid peroxidation,naturalantioxidative system and energy substances and the changes of phospholipid concentration inBAL fluid were also observed.The results were as follows:1.Inhalation of H₂S exerted a severe cytotoxic effect on the lung tissues resulting in dam-ages on various types of cells and a severe edematogenic effect on lung parenchyma.2.The development of pulmonary edema in H₂S intoxication resulted from a combination ofdifferent pathogenic factors.3.The biochemical changes and their recovery occurred earlier than the pathologicalchanges and their recovery.The efficacy of 6 categories of drugs including 25 medicaments against H₂S intoxication wasevaluated in mice,and 10 drugs were found to be prophylactically effective.The effects of vari-ous methemoglobin-forming agents and some other drugs were also studied in their treatment ofH₂S intoxication in rabbits and dogs.It was concluded that methemoglobin-forming agentscould be used as specific antidotes but could not provent or alleviate the lung damages due toH₂S inhalation unless they were administered in association with dexamethasone,vitamin E oranisodamine.A scheme of the medical treatment for H₂S intoxication was presented.Pulmonary injury after acute H_2S inhalation was studied with bronchoalveolar lavage (BAL),ultracentrifuge,and optical and electron microscopy.The changes of the activities of lactate dehydrogenase,alkaline and acid phosphatase,and angiotension converting enzymes in BAL fluid were used as the indicator of cellular damages,those of leucocytic count and the indi- cator of inflammatory response,and those of the concentration of protein and Evans blue as the indicator of vascular permeability.In addition the effects of H_2S on lipid peroxidation,natural antioxidative system and energy substances and the changes of phospholipid concentration in BAL fluid were also observed.The results were as follows: 1.Inhalation of H_2S exerted a severe cytotoxic effect on the lung tissues resulting in dam- ages on various types of cells and a severe edematogenic effect on lung parenchyma. 2.The development of pulmonary edema in H_2S intoxication resulted from a combination of different pathogenic factors. 3.The biochemical changes and their recovery occurred earlier than the pathological changes and their recovery. The efficacy of 6 categories of drugs including 25 medicaments against H_2S intoxication was evaluated in mice,and 10 drugs were found to be prophylactically effective.The effects of vari- ous methemoglobin-forming agents and some other drugs were also studied in their treatment of H_2S intoxication in rabbits and dogs.It was concluded that methemoglobin-forming agents could be used as specific antidotes but could not provent or alleviate the lung damages due to H_2S inhalation unless they were administered in association with dexamethasone,vitamin E or anisodamine.A scheme of the medical treatment for H_2S intoxication was presented.

关 键 词：hydrogen sulfide PULMONARY injury PULMONARY EDEMA INTOXICATION therapy methemoglobin-forming agent lipid PEROXIDATION 

分 类 号：R[医药卫生]