Alterations of mitochondrial function in ischemia/reperfusion cat heart  

作　　者：陈龙 张宝仁 朱家麟 陈如坤 郝家骅 陈晓晴 陈克明 

机构地区：[1]Now at Dept.of Thoracic and Cardiovascular Surgery,Fuzhou General Hospital,Nanjing Command of PLA,34 Guang Rong Road Fuzhou,350001 [2]Department of Thoracic Surgery,Changhai Hospital,Second Military Medical University,Shanghai 200433 [3]Department of Biochemistry,Second Military Medical University,Shanghai 200433

出　　处：《Journal of Medical Colleges of PLA(China)》1993年第4期337-341,共5页中国人民解放军军医大学学报（英文版）

摘　　要：The effect of myocardium being subjected to 60 min ischemia and 60 min reperfusion incat cardiopulmonary bypass on level of lipid peroxides(LPO),function of myocardial mitochon-dria and activity of superoxides dismutase(SOD)was studied. Myocardial mitochondrial functionwas depressed slightly 60 rain after ischemia but significantly 60 min after reperfusion.Increasedlipid peroxides content and decreased activity of SOD were observed at 60 rain after ischemia.Af-ter reperfusion,the activity of SOD continued decreasing,and LPO elevated still further.Theseresults support the hypothesis that free radicals may contribute to myocardial reperfusion injury.The effect of myocardium being subjected to 60 min ischemia and 60 min reperfusion in cat cardiopulmonary bypass on level of lipid peroxides(LPO),function of myocardial mitochon- dria and activity of superoxides dismutase(SOD)was studied. Myocardial mitochondrial function was depressed slightly 60 rain after ischemia but significantly 60 min after reperfusion.Increased lipid peroxides content and decreased activity of SOD were observed at 60 rain after ischemia.Af- ter reperfusion,the activity of SOD continued decreasing,and LPO elevated still further.These results support the hypothesis that free radicals may contribute to myocardial reperfusion injury.

关 键 词：ischemia reperfusion mitochondria HEART PEROXIDES SUPEROXIDES DISMUTASE CARDIOPULMONARY bypass cats 

分 类 号：R[医药卫生]