KINETICS OF DIFFUSION-CONTROLLED DRUG MATRICES RELEASE SYSTEM  

作　　者：王绍亭 杨志生 朱云仙 

出　　处：《Chinese Journal of Chemical Engineering》1993年第1期12-19,共8页中国化学工程学报（英文版）

摘　　要：A refined double integral method has been applied to the problem encountered in the diffu-sion release of a drug from a polymeric matrix.The finite external mass transfer resistance has alsobeen incorporated into the present analysis.Experimental release rates of 5-fluorouracil fromethylene-vinyl alcohol copolymer into distilled water were measured in order to test the applicabilityof these models.All system parameters were measured by experiments and models were built up.Themodels presented here are much more accurate than Higuchi model and much easier than the exactsolutions.In view of accuracy,the models are almost the same as the exact solutions.The experi-mental release data agree Well with the computedA refined double integral method has been applied to the problem encountered in the diffusion release of a drug from a polymeric matrix. The finite external mass transfer resistance has also been incorporated into the present analysis. Experimental release rates of 5-fluorouracil from ethylene-vinyl alcohol copolymer into distilled water were measured in order to test the applicability of these models. All system parameters were measured by experiments and models were built up. The models presented here are much more accurate than Higuchi model and much easier than the exact solutions. In view of accuracy, the models are almost the same as the exact solutions. The experimental release data agree well with the computed results.

关 键 词：diffusional controlled RELEASE ethylene- VINYL ALCOHOL COPOLYMER RELEASE KINETICS 

分 类 号：TQ-55[化学工程]