细胞外Ca^(2+)浓度对大鼠离体黄体细胞孕酮生成的影响  

Effect of extracellular calcium concent rationon progesterone production by isolated luteal cell of rat.

作　　者：金秀东[1] 王春梅[1] 滕芳姜 张书捷[2] 刘亚成[2] 李鹰[2] 

机构地区：[1]牡丹江医学院生理教研室 [2]牡丹江医学院机能教研室

出　　处：《牡丹江医学院学报》1993年第2期79-82,共4页Journal of Mudanjiang Medical University

摘　　要：用大鼠离体培养大、小黄体细胞,观察了细胞外Ca^(2+)浓度变化对大、小黄体细胞孕酮生成的影响。结果显示,用无Ca^(2+)、Mg^(2+)的KRBG液培养或增加细胞外Ca^(2+)浓度及培养液中加入EGTA时,对大、小黄体细胞孕酮生成均有影响,但对大黄休细胞的作用更为显著。这些结果一致表明,Ca^(2+)对大、小黄体细胞孕酮生成有促进作用,但在基础孕酮分泌中,大黄体细胞更明显依赖于细胞外液Ca^(2+)。The effect of extracellular calcium conceotration on progesterone prod-uction by large and small luteal cells of rat was studied. The results demo-nstrated that the progesterone production by isolated large and small luteal cells of rat was influnced by KRBG free of Ca2+, Mg2 + and different ext-racellular calcium concentration. However, the sensitivity to calcium was much greater in the large luteal cells than that in the small luteal cells. It is indicated that Ca2+ may promote progesterone production by the luteal cell, and progesterone production may depend on extracellular calcium concentration in isolated large and small luteal cells of rat, especially in basal secretion.

关 键 词：钙 EGTA 黄体细胞 孕酮 

分 类 号：R[医药卫生]