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作 者:李学斌[1] 王巨德[1] 李文智[1] 温艳东[1] 王春杰 周晓宏 郭连兴[2] 张秀芹[2]
机构地区:[1]承德医学院附属医院消化内科 [2]承德医学院附属医院检验科
出 处:《承德医学院学报》1993年第3期193-194,共2页Journal of Chengde Medical University
摘 要:用免疫散射比浊法检测血清补体C_3共88例,其中肝硬化合并肝癌组20例,肝硬化组28例,另设正常对照组40例。结果发现,补体C_3含量肝硬化合并肝癌组(0.972±0.329g/L)与肝硬化组(0.604±0.177g/L)之间有极显著差异(P<0.001)。血清补体C_3含量以0.99g/L为界限,则补体C_3对肝硬化合并肝癌诊断的阳性预测值、阴性预测值、准确度分别为84.6%、74.2%、77.08%,当补体C_3与AFP联合检测时则分别上升为94.4%、90.0%、91.6%,且较r—GT与AFP联合诊断肝硬化合并肝癌的价值有所提高,进一步证实血清补体C_3可以作为诊断肝硬化合并肝癌的重要标志物。Seram complement C_3 was determined with the nephelometric method in 88 cases including 20 cases of hepatocellular carcinoma (HCC), 28 liver cirrhosis(LC), 20 LC complicated by HCC and 40 healthy people. There was significant difference in complement C_3 content between the LC and LC complicated by HCC group. On condition that the complement C_3 content of 0.99g/L was selected as diagnostic limit,the positive prediction value,negative prediction value and accuracy were 84.6%, 74.2% and 77.08%respectively in the LC complicated by HCC group. When diagnosed with combined assay of C_3 and alpha-fetoprotein (AFP), the positive prediction value, negative prediction value and accuracy were elevated to 94.4%, 90.0%and 91.6%in proper order, which were higher than those with combined assay of serum r-glutamyltransferasre (r-GT) and AFP. These data further prove that complement C_3 is a important marker in diagnosing LC complicated by HCC patients.
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