二氧化硫对沥青烟气诱发小鼠肺癌影响的研究  

THE EFFECTS OF SO_2 ON THE CARCINOGENESIS OF MOUSE LUNG CANCER INDUCED BY PITCH SMOKE

作　　者：王江[1] 赵庆夏[1] 魏丽[1] 李新荣[1] 郭柯[1] 

机构地区：[1]河南医科大学病理学教研室,郑州450052

出　　处：《河南医学研究》1993年第3期206-209,共4页Henan Medical Research

摘　　要：本实验将150只昆明种小鼠随机分为三组(Ⅰ、Ⅱ、Ⅲ组)。Ⅰ、Ⅱ组小鼠同时吸入沥青烟气(浓度为165.50mg/M^3),每天3h,共4个月。Ⅱ组小鼠另每天附加吸入SO_22h(浓度为1.30mg/M^3)。Ⅲ组为空白对照组。整个实验周期为8个月,其中于实验第3和第6个月时,各组均随机处死小鼠6只,最后将剩余动物全部处死。结果:Ⅰ、Ⅱ组肺癌的总发生率均为79.17％(38/48),两者无差异。但Ⅱ组小鼠肺鳞癌的发生率显著高于Ⅰ组(P<0.05),而且多数Ⅱ组肺鳞癌发生早于Ⅰ组鳞癌。此结果提示,SO_2可能为肺鳞癌的促发因子。In this study, 150 Kunming mice were divided into three groups(group Ⅰ, Ⅱ and Ⅲ). All of the mice in group Ⅰ and Ⅱ inhaled pitch smoke together(in a concentration of 165. 50 mg/M^3)3 hours daily for 4 months. The mice in group Ⅱ inhaled additional SO_2(in a concentration of . 30 mg/M^3) for another 2 hours once a day. Group Ⅲ was designed as a control. The whole experiment lasted 8 months. Six of the mice in each group were killed at the third and sixth month in the experiment. The rest were killed at the end of the study. In both group Ⅰ and Ⅱ,the incidence of lung cancer was 79. 19% (38/48). There was not a significant difference between them. But the incidence of squamous cell carcinoma of the lung in group Ⅱ was markedly higher than that in group Ⅰ (P<0. 05). And most of the squamous cell carcinoma in group Ⅱ occured earlier than those in group Ⅰ. The results suggest that SO_2 might be a promoter in the carcinogenesis of squamous cell carcinoma of the lung.

关 键 词：二氧化硫 癌发生 小鼠 肺癌 

分 类 号：R[医药卫生]