男孩白血病治疗前后下丘脑-垂体-睾丸功能的探讨  

EVALUATION OF HYPOTHALAMIC-PITUITARY-TESTICULAR FUNCTION BEFORE AND AFTER COMBINATION CHEMOTHERAPY AND IRRADIATION FOR IEUKEMIA IN BOYS

作　　者：杨丽梅[1] 李争艳 张殿元[1] 张立忠[1] 刘玉明[1] 王淑珍 

机构地区：[1]中国医科大学附属第二医院儿科 [2]辽宁省气象局卫生所

出　　处：《中国医科大学学报》1993年第S1期90-95,共6页Journal of China Medical University

摘　　要：对4例初发未治疗、12例治疗后的白血病男孩做了LHRH和HCG刺激试验。结果表明,化疗可致儿童睾丸低功,青春期睾丸较青春期前更易受化疗的损害。导致睾丸低功的主要药物是CTX,用药的累积量越大对睾丸损害越重,睾丸接受放疗可致原发性睾丸低功,头部放疗可致继发性睾丸低功。对长期存活的白血病患儿应定期检查睾丸状态和/或功能,一旦发现异常,在继续治疗中应慎重应用对性腺有毒性的药物。初发未治疗、无髓外浸润的白血病患儿其下丘脑-垂体-睾丸功能正常。Gonadotropin responses to LHRH and testoterone responses to HCG were defined in 4 boys previously treated and 12 boys (prepuberty 8, puberty 4) treated for leukemia. The results were compared with those of 13 subjects matched for age and sex (prepuberty 5, puberty 3) with the LHRH test and HCG tests. There was primary testicular dysfunction of different degree in 2 prepubertal patients and 3 pubertal patiants, implying that the testis of pubertal boys is more vulnerable to chemotherapy than that of prepubertal boys. The drug associated with testicular dysfunction was cyclophosphamide. The resuits suggest that patients should be investigated for the function of their sexual gland in time. Once the abnormality is found, the drugs which are poisonous to their sexual gland should be used carefully in further treatment.

关 键 词：白血病 下丘脑-垂体-睾丸功能 

分 类 号：R[医药卫生]