运动疗法对非胰岛素依赖型糖尿病红细胞胰岛素受体的影响  

INFLUENCE OF EXERCISE THERAPY ON ERYTHROCYTE INSULIN RECEPTOR IN NON-DEPENDENT INSULIN-DEPENDENT DIABETES MELLITUS

作　　者：邸国勋 滕卫平[1] 邢殿友 王志勇[1] 张绍维[1] 富朴云 

机构地区：[1]中国医科大学附属第一医院内分泌科

出　　处：《中国医科大学学报》1991年第S1期35-37,41,共4页Journal of China Medical University

基　　金：国家自然科学基金

摘　　要：12例非胰岛素依赖型糖尿病患者以最大耗氧量60%的强度进行踏车锻炼1～2个月。一个疗程后血糖下降,GHb下降(P<0.05);血清IRI下降,体重减少(P<0.05)。红细胞胰岛素受体结合率(B/T)减低(P<0.05),高亲和力受体位点数及低亲和力受体位点数均减少(P<0.01)。B/T及两种受体位点数之变化与血清IRI和体重之变化均无相关。据以上结果推测,运动疗法改善非胰岛素依赖型糖尿病糖代谢,提高胰岛素敏感性的效果主要在于受体后过程。Cyclcergomer training with the intensity of VO_2 max 60% for 1～2months was performed in 12 NIDDM patients. At the end of the training coursethe mean blood sugar, GHb, serum IRI and body weight decreased. This wasaccompanied with a decrease of insulin binding to erythrocytes (B/T) and areduction of both high affinity insulin recepter binding sites (R_1) and lowaffinity binding sites (R_2). Furthermore these changes did not correlate withchanges of serun IRI and body weight. From this result we suggest that theeffect of exercise therapy causing improvement of glucose metabolism andenbancement of insulin sensitivity might originate with postrecepter events.

关 键 词：运动疗法 胰岛素受体 糖尿病 

分 类 号：R[医药卫生]