高温与CO联合作用下血液流变学的研究  

Combined Effects of Heat and Carbon Monoxide on Hemorheology

作　　者：陈萍[1] 张国高[1] 贺涵贞[1] 

机构地区：[1]同济医科大学公共卫生学院劳动卫生与职业病学教研室

出　　处：《华中科技大学学报（医学版）》1990年第S1期15-18,共4页Acta Medicinae Universitatis Scientiae et Technologiae Huazhong

基　　金：国家自然科学基金委员会资助课题

摘　　要：本文报道高温与CO联合作用对高脂膳食家兔血液流变学的研究。结果表明,实验40d,高温加CO组全血粘度(7.878±0.525mPa·s)、血浆粘度(1.814±0.066mPa·s)、红细胞压积(0.327±0.031)、血红蛋白(145.0±0.6g/L)、红细胞(667.2±59.4×10^(12)/L)明显高于常温组。由此提示,高温与CO联合作用可引起高脂膳食家兔血液流变学变化异常,促使冠心病的发生和发展。This paper reports on the combined effect of heat and carbon monoxide (CO) on hemorheology in rabbits (2~3 kg) fed on cholesterol (1g) and lard (4ml) everyday.All the rabbits were divided randomly into four groups,group A (35℃+750 mg/m3),B (35℃),C (25℃+750 mg/m3) and D (25℃).The exposure was carried out in a climatic chamber for 40 consecutive days (2hours daily).Our experimental results showed that.1.whole blood viscosity (WBV),plasma viscosity,hematocrit (HCT),hemoglobin (Hb),red blood cell (RBC) count and level of erythropoietin (Epo) of group B and A were.significantly increased.2.WBV (7.878±0.525 mPa·s),plasma viscosity (1.814±0.066mPa·s),HCT (0.327±0.031),Hb (145.0±0.6 g/L) and RBC (667.2±59.4×1012/L) were higher in group A than in group D by the 40th day of the exposure.The above results suggest that the combined effects of heat and CO may be associated with coronary heart disease.

关 键 词：高温 一氧化碳 血液流变学 胆甾醇 

分 类 号：R[医药卫生]