Changes of Gastric Mucosal Blood Flow in the Healing Process of Peptic Ulcers  

作　　者：李兆申 周岱云 许国铭 陈菊初 施雅芳 姚光弼 

机构地区：[1]Department of Gastroenterology,Changhai Hospital,Second Military Medical University,Shanghai 200433

出　　处：《Journal of Medical Colleges of PLA(China)》1990年第2期181-186,196,共7页中国人民解放军军医大学学报（英文版）

摘　　要：Changes of gastro-duodenal mucosal blood flow (GDMBF) in the healingprocess of 82 patients with gastric ulcer,130 with duodenal ulcer and 9 with active ul-cer induced by gastric polypectomy were studied by endoscopic laser Doppler flowme-try.In 108 normal subjects,the mucosal blood flow at the angle and antrum of the les-ser curvature and on the anterior wall of the duodenal bulb was the smallest (P【0.01).In patients with gastric ulcer,gastric mucosal blood flow (GMBF)significantly decrea-Sed at the active stage and increased at the healing stage (P【0.01 ).GDMBF significan-tly increased (P【0.01) at the active stage and returned to normal at the healing stage ofduodenal ulcer.GDMBF was unchanged in the healing process of the active ulcer inducedby gastric polypectomy.The mucosal blood flow at ulcer centre and margins significan-tly decreased at the active stage and markedly increased at the healing stage as compa-red with that of surrounding mucosa.We conclude that GMBF plays an importantrole in the developing and healing process of peptic ulcers.Changes of gastro-duodenal mucosal blood flow (GDMBF) in the healing process of 82 patients with gastric ulcer,130 with duodenal ulcer and 9 with active ul- cer induced by gastric polypectomy were studied by endoscopic laser Doppler flowme- try.In 108 normal subjects,the mucosal blood flow at the angle and antrum of the les- ser curvature and on the anterior wall of the duodenal bulb was the smallest (P<0.01). In patients with gastric ulcer,gastric mucosal blood flow (GMBF)significantly decrea- Sed at the active stage and increased at the healing stage (P<0.01 ).GDMBF significan- tly increased (P<0.01) at the active stage and returned to normal at the healing stage of duodenal ulcer.GDMBF was unchanged in the healing process of the active ulcer induced by gastric polypectomy.The mucosal blood flow at ulcer centre and margins significan- tly decreased at the active stage and markedly increased at the healing stage as compa- red with that of surrounding mucosa.We conclude that GMBF plays an important role in the developing and healing process of peptic ulcers.

关 键 词：GASTRIC MUCOSAL blood flow laser DOPPLER FLOWMETRY PEPTIC ULCERS 

分 类 号：R[医药卫生]