PRIMARY AMINE DRUG SELECTIVE ELECTRODES WITH SPECIAL CROWN ETHERS AS NEUTRAL CARRIERS*  

作　　者：刘昆元 俞汝勤 

机构地区：[1]Department of Chemistry and Chemical Engineering, Hunan University, Changsha 410012, PRC

出　　处：《Science China Chemistry》1990年第12期1466-1480,共15页中国科学（化学英文版）

基　　金：Project supported by the Science Foundation of the National Education Council, China. Part of work was done in Electroanalytical Chemistry Laboratory, Changchun Institute of Applied Chemistry, Academia Sinica.

摘　　要：Ionophores selectively sensitive to primary amines have been synthesized which display low potentiometric selectivity coefficients for K^+, Na^+ and NH_4^+ ions, secondary and tertiary amines as well as quaternary ammonium ions. These ionophores include macrocyclic polyethers with dinaphthyl subunits and azocrown ether with nitrogen donor atoms. The feasibility of these ionophores for preparing primary amine drug selective electrodes was investigated in detail. Practically usable PVC membrane electrodes sensitive to primary amine drugs, such as mexiletine, dopamine, metaraminol and tryptamine, and aliphatic primary amines have been prepared with these ionophores as neutral carriers. Direct potentiometric methods for assaying these drugs have been proposed by using the prepared electrodes. The proposed primary amine drug selective electrodes are remarkably superior to those based on ion-associates. Compared with the electrodes based on common ethers, the interference by K^+, Na^+ and NH_4^+ ions is substantially reduced. A digital simulation of the electrochemical process concerning the membrane transport was performed and some interesting conclusions have been drawn.Ionophores selectively sensitive to primary amines have been synthesized which display low potentiometric selectivity coefficients for K⁺, Na⁺ and NH₄⁺ ions, secondary and tertiary amines as well as quaternary ammonium ions. These ionophores include macrocyclic polyethers with dinaphthyl subunits and azocrown ether with nitrogen donor atoms. The feasibility of these ionophores for preparing primary amine drug selective electrodes was investigated in detail. Practically usable PVC membrane electrodes sensitive to primary amine drugs, such as mexiletine, dopamine, metaraminol and tryptamine, and aliphatic primary amines have been prepared with these ionophores as neutral carriers. Direct potentiometric methods for assaying these drugs have been proposed by using the prepared electrodes. The proposed primary amine drug selective electrodes are remarkably superior to those based on ion-associates. Compared with the electrodes based on common ethers, the interference by K⁺, Na⁺ and NH₄⁺ ions is

关 键 词：primary AMINE DRUG selective electrodes CROWN ETHERS with dinaphthyl SUBUNITS neutral carriers IONOPHORES 

分 类 号：O6[理学—化学]