高剂量率后装联合体外放射治疗鼻咽癌早期临床研究  

HIGH-DOSE RATE AF-TERLOADING INTRACAVITARY RADIOTHERAPY COMBINED WITH EXTERNAL IRRADIATION FOR CARCINO.MA OF THE NASOPHARYNX - A pilot study on 42 patients

作　　者：郎锦义[1] 陈念永[1] 车字伟 文浩[1] 许峰[1] 张新忠[1] 王静波[1] 

机构地区：[1]四川省肿瘤医院

出　　处：《中华放射肿瘤学杂志》1990年第2期26-29,共4页Chinese Journal of Radiation Oncology

摘　　要：单纯体外放射治疗为公认的鼻咽癌治疗方法,通常给予原发灶66～70Gy,然而疗后仍有13.2％病例有残留癌,30～40％病例局部复发。近年来已有作者,采用腔内后装对鼻咽癌加量放射治疗。From 1985 to 1989, 42 patients with cancer of the nasopharynx were treated with high-dose rate afterloading intracavitary radiotherapy combined with external irradiation (EXRT). Twenty-seven patients had lesions previously not treated. All were followed for 6-15 months. The primary lesion was treated with EXRT 50-56 Gy in combination with HDR-ICRT 6 Gy per fraction, 2 fractions per week to a total dose of 18 or 24 Gy. The total tumor dose (EXRT+HDR-IGRT) was kept 73-74 Gy at Point C for radical treatment. There was no severe acute radiation reaction. Althouth the follow-up period was limited the authors consider the results are encouraging. This new method was inappropriate for extensive lesions involving the maxillary sinus or temporamazillary fossa.

关 键 词：高剂量率后装 放射治疗 早期临床 剂量参考点 局部控制率 咽旁间隙 肿瘤剂量 鼻咽部 残留病灶 等剂量曲线 

分 类 号：R73[医药卫生—肿瘤]