硝苯吡啶乳膏的研制及其经皮给药治疗高血压的临床疗效  

CLINICAL EFFECT OK TREATMENT OF PREPARATION OF NIFEDIPINE CREAM ON HYPERTENSION BY ENDERMISM

作　　者：刘吉成[1] 刘玉梅[2] 陈伯雄 张淑云 

机构地区：[1]齐齐哈尔医学院第一附属医院制剂室 [2]齐齐哈尔医学院第一附属医院内科 [3]齐齐哈尔钢厂职工医院

出　　处：《齐齐哈尔医学院学报》1990年第1期10-12,16,共4页Journal of Qiqihar Medical University

摘　　要：笔者研制的o/w 型硝苯吡啶乳膏,以二甲亚砜和1,2-丙二醇为透皮促进剂,经皮给药治疗高血压病人22例,显效14例,有效7例,总有效率95.45％。用药后4.19±1.62min血压开始下降,22.14±8.74min血压下降达最大值,降压效应持续5.71±2.17h。降压起效时间比氮酮硝苯吡啶乳剂快58.26倍,比口服给药快4.77倍,与口含相当。心率在用药后明显下降(p<0.05),与许多报道不一致,可能与用药方式和给药途径有关。Twenty two patients, suffered from hypertension, were treated with a new form of nifedipine cream, using DMSO and 1.2-propylene glycol as a accelaretor for percutaneous absorption, that was invented by us. 14 of 22 cases get remarkable effect and 7 get effect for endermism of nifedi-pine cream. The total effective rate was 95.45%. The hypotensive effect started at the interval of 4.13+1.62min after treatment, and reaching the the maximum hypotensive value at 22.14+8.74min. The persistence time of hypotensive action was 5.17+2.17hrs. After treatment, the initiated time of the hypotensive action was 58.26 times earlier than that of Arzone Nifedipine Cream and 4.77 times earlier than that of oral administration and was approximately the same as that of a sublingual dose (p<0.05), which was different from that reported previously.The difference of heart rate change may be related to the pattern and route of the administration of nifedipine.

关 键 词：硝苯吡啶 高血压 心率 经皮给药 二甲亚砜 

分 类 号：R[医药卫生]