幽门弯曲菌致病性的临床病理研究  

Clinic Pathological Study for Pathogenicity of Campylobacter Pyloridis

作　　者：吴忠舜[1] 曾习明[1] 刘世业 易萍 

机构地区：[1]华西医科大学附属职业病防治院病理科 [2]四川省隆昌县人民医院胃镜室

出　　处：《临床消化病杂志》1990年第3期111-114,共4页Chinese Journal of Clinical Gastroenterology

摘　　要：本文观察了107例胃镜活检标本的的HE、Giemsa和Warthin-Starry’s染色切片.CP量与胃炎严重程度,与胃炎活动性,与胃上皮损伤的严重程度之间均呈正相关(P<0.01)CP有不同的排列方式:垂直于胃上皮表面,临跨上皮细胞内外,垂直侵袭并占据细胞间隙,存在于胃上皮细胞分泌泡内(52/60)。这一切清楚地表明了CP具有细胞致病作用,胃窦粘液上皮细胞则为其优先攻击靶.107 gastroendoscopic biopsy specimens stained by HE, GIEMSA and WARTHIN-STARRY'S methods were observed, A close relationship was found between the quantity of the bacteria and the inflammatory severity, inflammatory activity, and severity of antral epithelial injury(P<0.0l). Different distributive patterns of CP were seen: erecting on the surface of the epithelium, partially crossing the surface of the memberane of cells; verticelly infiltrating and occupying the clefts between cells and expanding the clefts; or presenting in the cytoplasmic secretory vacuales of gastric epithelial cells (52/69), All the findings suggest that CP showed a cytopathogenic role and the mucous cells appeared to be the prefrential target site.

关 键 词：幽门弯曲菌 细胞致病作用 粘液上皮细胞 

分 类 号：R57[医药卫生—消化系统]