乳腺原发性前驱T淋巴母细胞淋巴瘤1例报道并文献复习  

Breast precursor T-cell lymphoblastic lymphoma:report of a case and review of literature

作　　者：李良[1,2] 郭庆[1] 张正祥[1] 吴波[1] 周航波[1] 王海[1] 石群立[1] 

机构地区：[1]南京大学医学院临床学院南京军区南京总医院病理科,江苏南京210002 [2]南京大厂医院病理科

出　　处：《诊断学理论与实践》2011年第5期463-466,共4页Journal of Diagnostics Concepts & Practice

摘　　要：目的:探讨1例乳腺原发性前驱T淋巴母细胞淋巴瘤患者的临床病理特征、诊断与鉴别诊断。方法:对1例乳腺原发性前驱T淋巴母细胞淋巴瘤患者的病理组织进行光镜和免疫组化检测,并结合文献复习。结果:组织学镜检见肿瘤细胞呈弥漫浸润性生长,肿瘤细胞中等大小,胞质少,核染色质细颗粒状,核分裂象多见。免疫表型示,瘤细胞呈CD3、CD5、CD43和末端脱氧核苷酸转移酶(TdT)、CD79α阳性,T细胞活化连接蛋白(LAT)、CD10、bcl-2散在阳性;Pax-5、CD20、CD99和MPO均阴性,Ki-67增殖指数为40%。结论:前驱T淋巴母细胞淋巴瘤是一种较为少见的高度恶性肿瘤,原发于成人乳腺者极为罕见,而其诊断及鉴别诊断主要依赖于病理形态学和免疫组化标志。Objective To report a case of primary breast precursor T-cell lymphoblastic lymphoma and to study its clinical and pathologic features,diagnosis and differential diagnosis.Methods A case of breast precursor T-cell lymphoblastic lymphoma was studied by light microscopy and immunohistochemical staining together with review of literature.Results The female patient was 32 years old.Histologically,the tumor cells were median-sized,showing a diffuse infiltration.The neoplastic cells had a high nuclear-cytoplastic ratio and the chromatin was finely granular.Nuclei mitosis was frequently seen.Immunophenotyping showed that the tumor cells were positive for CD3,CD5,CD43,CD79α and TdT,and scatterly positive for LAT,CD10 and bcl-2.While Pax-5,CD20,CD99 and MPO were negative.The Ki-67 proliferation index was 40%.Conclusions Precursor T-cell lymphoblastic lymphoma is a relatively rare malignant tumor and is very rare as a primary breast tumor in adult.The diagnosis and differential diagnosis are based on pathologic features and immunohistochemical markers.

关 键 词：乳腺 前驱T淋巴母细胞淋巴瘤 免疫组化 诊断 

分 类 号：R737.9[医药卫生—肿瘤]