远视儿童应用1％环喷托酯睫状肌麻痹验光的研究  

Research of cyclopentolate 1% on the effect of cycloplegia for Chinese hyperopic children

作　　者：王晓明[1] 马鲁新[1] 王利华[1] 

机构地区：[1]山东大学附属省立医院眼科中心,济南250021

出　　处：《中华眼科杂志》2011年第11期989-994,共6页Chinese Journal of Ophthalmology

摘　　要：目的探讨远视儿童应用1％环喷托酯滴眼液以及联合应用表面麻醉药丙美卡因滴眼液的远视屈光度的峰值时间，并比较应用1％环喷托酯与1％阿托品睫状肌麻痹验光的屈光度值的差异。方法采用简单随机化分组方法将71例（141只眼）远视儿童[年龄（7．9±2．1）岁]分为A组（Pro＋Cyc组）和B组（NS＋Cyc组）。两组均于1％环喷托酯首次滴眼后30、40、50、60、70min进行电脑验光和瞳孑L直径测量，1周后给予1％阿托品凝胶点眼，连用3d后重复上述测量，分别为A’组及B’组。在对各组数据进行正态性检验及方差齐性分析后，应用重复测量数据的方差分析分别对A组、B组各时间点的电脑验光屈光度值及瞳孔直径进行比较；应用配对t检验分别对A组、B组各时间点电脑验光屈光度数与A’组、B’组电脑验光屈光度数进行比较；应用两组独立样本的t检验对A组屈光度数的峰值与A’组屈光度数的差值和B组屈光度数的峰值与B’组屈光度数的差值进行比较。结果A组和B组屈光度数的峰值分别出现在1％环喷托酯首次滴眼后50和60min。A组与A’组屈光度数峰值分别为（＋4．44±2．34）和（＋4．86±2．29）D，两者比较差异有统计学意义（t=11．16，P〈0．01）；B组与B’组屈光度数峰值分别为（＋4．50±2．19）和（＋5．04±2．10）D，两者比较差异有统计学意义（t=11．44，P〈0．01）。A组屈光度数峰值与A’组屈光度数间的差异小于B组屈光度数峰值与B’组屈光度数间的差异（t=-1．99，P=0．048）。A组和B组瞳孔直径的峰值分别出现在1％环喷托酯首次滴眼后50和60min，均与其屈光度的峰值时间一致。结论在我国3～14岁远视儿童中，单独应用1％环喷托酯滴眼3次，在首次滴眼后50至70min验光可测得其最大的屈光度数；1％环喷托酯联合应用表面麻醉剂丙美卡因可使其峰值时间提前约10miObjective To investigate the peak time of refractive error obtained by Cyclopentolate Hydrochloride 1.0% （ Cyclopentolate 1.0% for short ） and Cyclopentolate 1.0% combined with Proparacaine Hydrochloride O. 5% （Proxymetacaine） and to compare the refractive error obtained by Cyclopentolate 1.0% and Atropine 1.0% in the children with hyperopia. Methods Seventy one children （ 141 eyes） with hyperopia （ mean age 7.9±2. 1 ） were divided into two groups randomly according to the different cycloplegic methods ：group A （Pro ＋ Cyc group） and group B （NS ＋ Cyc group）. There were 34 patients （67 eyes ） in group A and 37 patients （74 eyes ） in group B. One drop of Proparacaine Hydrochloride 0. 5% or physiological saline was used respectively in group A and group B, five minutes before three drops of Cyclopentolate 1.0% were given at intervals of ten minutes. Cycloplegic autorefractions and pupil diameter were compared at 30,40,50,60,70minutes after the first drop of Cyclopentolate 1.0% was given in both A and B groups. Atropine 1.0% was used in both groups one week later for three days with three times per day （group A＇ and group B＇）. Cycloplegic autorefractions and pupil diameter were compared between group A and A,＇ and group B and B＇, respectively. Results The peak time of cycloplegic autorefractions was 50 minutes after the first drop of cyclopentolate 1.0% in group A, while the peak time was 60 minutes in group B. The maximal cycloplegic autorefraction of group A was significantly lower than that in groupA＇ [（ ＋4.44±2.34）D vs. （ ＋4.86±2.26）D, t =11.16, P〈0.01]. The maximal cycloplegic autorefraction of group B was significantly lower than that in group B＇ [ （ ＋ 4. 50±2. 19）D vs. （ ＋ 5.04±2. 10） D, t = 11.44, P 〈 0. 01 ]. The difference of cycloplegic autorefractions between group A＇ and the peak refraction of group A was less than the difference between group B＇ and the peak refraction of group B [ （0.42± 0. 32） D vs. （0. 5

关 键 词：远视 丙氧卡因 环喷托酯 阿托品 儿童 屈光 眼 

分 类 号：R778.11[医药卫生—眼科]