肠上皮细胞的免疫调节与炎症性肠病  

Immunoregulation of intestinal epithelial cells and its relevance to inflammatory bowel disease

作　　者：曾敬清[1] 刘伟[1] 周同[1] 林凯[1] 许春娣[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院,上海200025

出　　处：《临床儿科杂志》2011年第11期1092-1095,共4页Journal of Clinical Pediatrics

基　　金：国家自然科学基金项目资助(No.30770999;No.81000163);上海市科委基础研究重点项目基金资助(No.09JC1409900);上海市自然科学基金项目资助(No.10ZR1419600)

摘　　要：肠上皮细胞由于其特殊的解剖位置,作为抵御抗原入侵的免疫防御首道防线,其在肠黏膜屏障中发挥着重要免疫调节作用而日趋受到关注。上皮细胞在接触病原微生物或受损时,可通过产生趋化因子、细胞因子招募炎症细胞;抑或以直接激活或转分化方式,与黏膜固有层免疫细胞相互作用,以调节微环境中炎症及免疫反应的格局。从这个意义上来说,肠上皮细胞不仅是肠黏膜物理屏障,更可能是内外环境信号转导枢纽,并在调节肠黏膜固有免疫防御及损伤-修复的平衡中发挥不可或缺的重要作用。肠道疾病尤其是炎症性肠病(IBD)正常以黏膜损伤、溃疡形成为主要表现,与肠黏膜屏障功能改变密切相关。为此,基于上皮细胞生物学功能及其免疫调节角度对此作深入探讨,可为IBD相关研究以及临床诊疗提供新的思路和策略。With a special anatomical location,intestinal epithelial layer is an important barrier against antigen invasion.Its immunomodulatory role in mucosal immunity attracted considerable attention.When epithelial cells contact with pathogenic microorganisms or they are injured,the epithelial cells could interact with immunocyte in mucosal lamina propria,to recruit inflammatory cells by producing chemokines,cytokines,or by the ways of directly activated and transdifferentiation,to regulate the inflammatory or immune response in microenvironment.In this sense,intestinal epithelial layer is not only a physical barrier,but also a hinge of signal transduction in exterior and interior environment,also plays an important role in regulating intestinal mucosal inherent immunity and keeping the balance of injury and repair.As the main clinical manifestations of bowel disease,especially in inflammatory bowel disease,mucosal injury and ulcer associate closely with the changes of intestinal barrier function.So,based on the biological function and immune regulation of intestinal epithelial cells,further discussion could offer new ideas and strategies on inflammatory bowel disease-related research and clinical diagnosis.

关 键 词：炎症性肠病 黏膜屏障 上皮细胞 免疫调节 

分 类 号：R574[医药卫生—消化系统]