恶性腹腔积液体外高频深部热疗联合腹腔化疗的临床观察  

Clinical research of external high frequency hyperthermia plus perfusion chemotherapy on malignant peritoneal effusion

作　　者：李海金[1] 董良[1] 陈亚男[1] 李英[1] 尚官敏[1] 葛丽娜[1] 赵建刚[1] 王伟英[1] 方萍[1] 

机构地区：[1]中国医科大学绍兴医院肿瘤内科,浙江绍兴312030

出　　处：《中华肿瘤防治杂志》2011年第19期1559-1562,共4页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的:观察体外高频深部热疗联合腹腔化疗治疗恶性腹腔积液的近期疗效和不良反应。方法:70例患者随机分为体外高频深部热疗联合腹腔化疗组(治疗组)35例和单用腹腔化疗组(对照组)35例,均采用中心静脉导管腹腔内置管引流,引流量1 000～2 000mL/d,需3～5d,最大限度引尽腹腔积液后经中心静脉导管注入分别含有顺铂40 mg/m2、5-氟尿嘧啶750mg/m2、地塞米松10mg的生理盐水1 500～2 000mL,肝素帽封管,嘱患者每10min变换体位1次使药物在腹腔内分布均匀。治疗组于给药后30min开始腹部体外高频深部热疗,设定治疗温度43℃,持续1h,对照组单用腹腔化疗,两组均每周1次共3次,然后评定近期疗效,观察不良反应。结果:治疗组完全缓解(CR)23例,部分缓解(PR)8例,有效率(RR)88.58%;对照组CR 12例,PR 10例,RR62.86%;两组比较差异有统计学意义,χ2=6.29,P=0.01。Kamofsky评分改善分别是27例(77.14%)和18例(51.43%),两组比较差异有统计学意义,χ2=5.04,P=0.02。不良反应均能耐受,两组比较差异无统计学意义,P>0.05。结论:体外高频深部热疗联合腹腔化疗治疗恶性腹腔积液疗效明显提高,不良反应减轻。OBJECTIVE： To observe the short-term effect and toxicity of external high frequency hyperthetrnia plus intraperitoneal chemotherapy on malignant peritoneal effusiora METHODS： A total of 70 patients with malignant peritoneal effusion were divided randomly into two groups-external high frequency hyperthermia plus intraperitoneal chemotherapy group （treatment group, 35 cases） and intraperitoneal chemotherapy alone group （control group, 35 cases）. All patients were performed abdominocentesis with central venous catheter. The amount of drainage was about 1 000--2 000 mL per day for 3-- 5 days. When was completely drained,normal saline （1 500--2 000 mL） with cisplatin （40 mg/m2 ）,fluorouracil （750 mg/m2 ） and dexamethasone （10 mg） respectively was perfused through central venous catheter into peritoneal cavity,and asked all patients change their position every 10 minutes to make sure the drug was uniforrrL In the treatment group,after 30 minutes when given the drugs,all patients were received external high frequency hyperthermia at 43℃ for one hour, While in the control group patients were only given the drugs. Both of them were repeated weekly for three times. The evaluation of the short-term effect, toxicity was performed after the therapy. RESULTS： The response rate of the treatment group was 88. 58% which including 23 patients who were complete remission and 8 patients who were partial remission, and the response rate of the control group was 62.86% which including 12 patients who were complete remission and 10 patients who were partial remission. There was significant differences between two groups （9（2 6. 29,P=0. 01）. There were 27 patients （77. 14%） whose KPS score increased in treatment group and 18 patients（51.43%） in control group,and there were also significant differences between two groups （χ2=5.04, P = 0. 02）. The incidence of toxicity in two groups was low and being not statistically significant （P 〉0. 05）. OONCLUSION： The treatment of external h

关 键 词：胸腔积液 恶性/治疗 抗肿瘤药 高温 诱发 注射 腹腔内 治疗结果 

分 类 号：R730.5[医药卫生—肿瘤]